A7GRL8 (LSPA_BACCN) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 39.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Lipoprotein signal peptidase EC=3.4.23.36 Alternative name(s): Prolipoprotein signal peptidase Signal peptidase II Short name=SPase II | ||||
| Gene names |
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| Organism | Bacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 315749 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group |
Protein attributes
| Sequence length | 152 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity. HAMAP MF_00161 |
| Catalytic activity | Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. HAMAP MF_00161 |
| Pathway | Protein modification; lipoprotein biosynthesis (signal peptide cleavage). HAMAP MF_00161 |
| Subcellular location | Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00161. |
| Sequence similarities | Belongs to the peptidase A8 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | Aspartyl protease Hydrolase Protease |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | proteolysis Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | aspartic-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 152 | 152 | Lipoprotein signal peptidase HAMAP MF_00161 | PRO_1000190792 | |||||
Regions | |||||||||
| Transmembrane | 55 – 75 | 21 | Helical; Potential | ||||||
| Transmembrane | 85 – 105 | 21 | Helical; Potential | ||||||
| Transmembrane | 124 – 144 | 21 | Helical; Potential | ||||||
Sites | |||||||||
| Active site | 102 | 1 | By similarity | ||||||
| Active site | 129 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NVH 391-98. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000764 Genomic DNA. Translation: ABS22776.1. |
| RefSeq | YP_001375771.1. NC_009674.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A7GRL8. |
Protein family/group databases | |
| MEROPS | A08.001. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBBACT00000038646; EBBACP00000037697; EBBACG00000038637. |
| GeneID | 5344022. |
| GenomeReviews | Gene locus Bcer98_2542 in contig CP000764_GR. |
| KEGG | bcy:Bcer98_2542. |
| PATRIC | 18933682. VBIBacCyt128034_2685. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0597. |
| GeneTree | EBGT00050000001848. |
| HOGENOM | HBG724422. |
| OMA | IASEIHG. |
| ProtClustDB | PRK00376. |
Enzyme and pathway databases | |
| BioCyc | BCER315749:BCER98_2542-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00161. LspA. [Tree] |
| InterPro | IPR001872. Peptidase_A8. [Graphical view] |
| KO | K03101. |
| Pfam | PF01252. Peptidase_A8. 1 hit. [Graphical view] |
| PRINTS | PR00781. LIPOSIGPTASE. |
| TIGRFAMs | TIGR00077. LspA. 1 hit. |
| PROSITE | PS00855. SPASE_II. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LSPA_BACCN | ||||||||
| Accession | Primary (citable) accession number: A7GRL8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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