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A7GQB6

- PCP_BACCN

UniProt

A7GQB6 - PCP_BACCN

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Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Bacillus cereus subsp. cytotoxis (strain NVH 391-98)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei80 – 801UniRule annotation
Active sitei143 – 1431UniRule annotation
Active sitei167 – 1671UniRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. pyroglutamyl-peptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciBCYT315749:GH2A-2168-MONOMER.

Protein family/group databases

MEROPSiC15.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidaseUniRule annotation (EC:3.4.19.3UniRule annotation)
Alternative name(s):
5-oxoprolyl-peptidaseUniRule annotation
Pyroglutamyl-peptidase IUniRule annotation
Short name:
PGP-IUniRule annotation
Short name:
PyraseUniRule annotation
Gene namesi
Name:pcpUniRule annotation
Ordered Locus Names:Bcer98_2056
OrganismiBacillus cereus subsp. cytotoxis (strain NVH 391-98)
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002300: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytosol Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Pyrrolidone-carboxylate peptidasePRO_1000080514Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi315749.Bcer98_2056.

Structurei

3D structure databases

ProteinModelPortaliA7GQB6.
SMRiA7GQB6. Positions 1-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2039.
HOGENOMiHOG000242641.
KOiK01304.
OMAiHRTIVER.
OrthoDBiEOG6X1124.

Family and domain databases

Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
TIGRFAMsiTIGR00504. pyro_pdase. 1 hit.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7GQB6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTVLLTGFD PFGGEKINPA WEVAKALHEK EGNGYKVISK QIPTVFHKSI
60 70 80 90 100
EQLESYIDEF NPELIICIGQ AGGRADITVE RVAINVDDAR IPDNENYQPI
110 120 130 140 150
DVPIIEDGPV AYWSTLPIKA IVKKLREEGI PASVSQTAGT FVCNHLFYGL
160 170 180 190 200
MHRLAIKNKS TRGGFVHIPF LPEQASLHAN QPSMSLSTII AGIQLLIEVA
210
LQVEKDIVEC GGTTH
Length:215
Mass (Da):23,613
Last modified:September 11, 2007 - v1
Checksum:iE6B0DBAB6897F75A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000764 Genomic DNA. Translation: ABS22324.1.
RefSeqiYP_001375319.1. NC_009674.1.

Genome annotation databases

EnsemblBacteriaiABS22324; ABS22324; Bcer98_2056.
GeneIDi5344298.
KEGGibcy:Bcer98_2056.
PATRICi18932672. VBIBacCyt128034_2180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000764 Genomic DNA. Translation: ABS22324.1 .
RefSeqi YP_001375319.1. NC_009674.1.

3D structure databases

ProteinModelPortali A7GQB6.
SMRi A7GQB6. Positions 1-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315749.Bcer98_2056.

Protein family/group databases

MEROPSi C15.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS22324 ; ABS22324 ; Bcer98_2056 .
GeneIDi 5344298.
KEGGi bcy:Bcer98_2056.
PATRICi 18932672. VBIBacCyt128034_2180.

Phylogenomic databases

eggNOGi COG2039.
HOGENOMi HOG000242641.
KOi K01304.
OMAi HRTIVER.
OrthoDBi EOG6X1124.

Enzyme and pathway databases

BioCyci BCYT315749:GH2A-2168-MONOMER.

Family and domain databases

Gene3Di 3.40.630.20. 1 hit.
HAMAPi MF_00417. Pyrrolid_peptidase.
InterProi IPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
[Graphical view ]
PANTHERi PTHR23402. PTHR23402. 1 hit.
Pfami PF01470. Peptidase_C15. 1 hit.
[Graphical view ]
PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSi PR00706. PYROGLUPTASE.
TIGRFAMsi TIGR00504. pyro_pdase. 1 hit.
PROSITEi PS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NVH 391-98.

Entry informationi

Entry nameiPCP_BACCN
AccessioniPrimary (citable) accession number: A7GQB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3