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Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Manganese 1UniRule annotation1
Metal bindingi13Manganese 1UniRule annotation1
Metal bindingi15Manganese 2UniRule annotation1
Metal bindingi75Manganese 1UniRule annotation1
Metal bindingi75Manganese 2UniRule annotation1
Metal bindingi97Manganese 2UniRule annotation1
Metal bindingi149Manganese 2UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaCUniRule annotation
Ordered Locus Names:Bcer98_1924
OrganismiBacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002300 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000779751 – 310Probable manganese-dependent inorganic pyrophosphataseAdd BLAST310

Interactioni

Protein-protein interaction databases

STRINGi315749.Bcer98_1924

Structurei

3D structure databases

ProteinModelPortaliA7GQ01
SMRiA7GQ01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2M Bacteria
COG1227 LUCA
HOGENOMiHOG000223999
KOiK15986
OMAiSTPLECW
OrthoDBiPOG091H00ML

Family and domain databases

Gene3Di3.10.310.20, 1 hit
HAMAPiMF_00207 PPase_C, 1 hit
InterProiView protein in InterPro
IPR001667 DDH_dom
IPR004097 DHHA2
IPR038222 DHHA2_dom_sf
IPR022934 Mn-dep_inorganic_PyrPase
PfamiView protein in Pfam
PF01368 DHH, 1 hit
PF02833 DHHA2, 1 hit
SMARTiView protein in SMART
SM01131 DHHA2, 1 hit

Sequencei

Sequence statusi: Complete.

A7GQ01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVLVFGHK NPDTDAICSA IAYAELKKEL GMNAEPVRLG EISGETQFAL
60 70 80 90 100
DYFKVEGPRF VETVANEVDN VILVDHNERQ QSANDIESVR VLEVIDHHRI
110 120 130 140 150
ANFETSDPLY YRCEPVGCTA TILNKMYKEN GVAIRKEIAG LMLSAIISDS
160 170 180 190 200
LLFKSPTCTE QDVAAARELA EIAGVDAESY GLEMLKAGAD LSGKTMEQLI
210 220 230 240 250
SLDAKEFQMG NAKVEIAQVN AVDTNDVLVH QAELEKVISA VVEEKGLDLF
260 270 280 290 300
LFVVTDILTN DSVGLAIGKA ANAVEKAYNV TLENNTATLK GVVSRKKQIV
310
PVLTETFQAL
Length:310
Mass (Da):33,821
Last modified:September 11, 2007 - v1
Checksum:iAC072DBFB270643C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA Translation: ABS22209.1
RefSeqiWP_012094402.1, NC_009674.1

Genome annotation databases

EnsemblBacteriaiABS22209; ABS22209; Bcer98_1924
GeneIDi33897231
KEGGibcy:Bcer98_1924

Similar proteinsi

Entry informationi

Entry nameiPPAC_BACCN
AccessioniPrimary (citable) accession number: A7GQ01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health