A7GPY2 (KYNB_BACCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
EC=3.5.1.9

Alternative name(s):
N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	Bcer98_1902

Organism

Bacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]

Taxonomic identifier

315749 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB formamidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Kynurenine formamidase		PRO_0000362090

Sequences

	Sequence		Length	Mass (Da)
	A7GPY2 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 502E2000368D7A1C	FASTA	209	23,004
	10 20 30 40 50 60 MKASEWIDIS QPLNNEIATW PGDTPFSYEV SCTKEQSGSV NIGKVTMSIH TGTHIDAPFH 70 80 90 100 110 120 FDNDGKKVID LDIHVYVGPA RIIDVSSMDS IGVKELQQFN LEGVERLLLR TSSHGNAQKF 130 140 150 160 170 180 PDIIPFLCAE IAPFLSKKGV RLIGVDVPSV DPLDDKELAA HHQLFQHGIH ILENVVLDHV 190 200 QDGDYELIAL PLALTEADGS PVRAIIRPL

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NVH 391-98.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000764 Genomic DNA. Translation: ABS22190.1.
RefSeq	YP_001375185.1. NC_009674.1.
3D structure databases
ProteinModelPortal	A7GPY2.
ModBase	Search...
Protein-protein interaction databases
STRING	A7GPY2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000036426; EBBACP00000035477; EBBACG00000036417.
GeneID	5346613.
GenomeReviews	Gene locus Bcer98_1902 in contig CP000764_GR.
KEGG	bcy:Bcer98_1902.
PATRIC	18932332. VBIBacCyt128034_2010.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1878.
GeneTree	EBGT00050000003083.
HOGENOM	HBG686791.
OMA	HTSKWPL.
ProtClustDB	CLSK904617.
Enzyme and pathway databases
BioCyc	BCER315749:BCER98_1902-MONOMER.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
KO	K07130.
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. Trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_BACCN

Accession

Primary (citable) accession number: A7GPY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	September 11, 2007
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program