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Reviewed, UniProtKB/Swiss-Prot A7GPH3 (IOLA_BACCN)

Last modified June 16, 2009. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Methylmalonate semialdehyde dehydrogenase [acylating]
      Short name=MMSA dehydrogenase
      Short name=MMSDH
      Short name=MSDH
    EC=1.2.1.27
Alternative name(s):
    Malonate semialdehyde dehydrogenase [acetylating]
      Short name=MSA dehydrogenase
    EC=1.2.1.18
Gene names
Name: iolA
Ordered Locus Names: Bcer98_1729
OrganismBacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]
Taxonomic identifier315749 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

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Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively By similarity.

Catalytic activity

3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. HAMAP MF_01670

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH. HAMAP MF_01670

Pathway

Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 7/7. HAMAP MF_01670

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family. IolA subfamily.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Methylmalonate semialdehyde dehydrogenase [acylating] HAMAP MF_01670
PRO_0000352325

Regions

Nucleotide binding178 – 1825NAD By similarity

Sites

Active site2861Nucleophile By similarity
Binding site3861NAD By similarity

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Sequences

Sequence LengthMass (Da)Tools
A7GPH3-1 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: E4FB74AAB1150AED

FASTA48653,142
        10         20         30         40         50         60 
MITTEIKRVK NHINGEWVES TGTEVEAVPN PATGKIIAYV PLSPKEDVER AVEAAKNAYE 

        70         80         90        100        110        120 
TWSKVPVPNR SRMLYKYLQL LQENKDELSK IITLENGKTL KDASGEVQRG IEAVELATSA 

       130        140        150        160        170        180 
PNLMMGQALP NIAGGIDGSI WRYPLGVVAG ITPFNFPMMI PLWMFPLAIA CGNTFVLKTS 

       190        200        210        220        230        240 
ERTPLLAERL VELFYEAGFP KGVLNLVQGG KEVVNSILEN KEIQAVSFVG SEPVARYVYE 

       250        260        270        280        290        300 
TGTKYGKRVQ ALAGAKNHAI VMPDCNLEKT VQGVIGSAFG SSGERCMACS VVAVLDEIAD 

       310        320        330        340        350        360 
EFIDALVSET RKLKVGDGFH EENYVGPLIR ESHKERVIGY INSGVADGAS LLVDGRQIKE 

       370        380        390        400        410        420 
DVEGGYFVGA TIFDGVNQNM KIWQDEIFAP VLSIVRVRDL EEGIQLTNQS KFANGAVIYT 

       430        440        450        460        470        480 
SSGKHAQTFR DHIDAGMIGV NVNVPAPMAF FAFAGNKASF YGDLGTNGKD GVQFYTRKKV 


VTERWF

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References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000764 Genomic DNA. Translation: ABS22031.1.
RefSeqYP_001375026.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID5345355.
GenomeReviewsGene locus Bcer98_1729 in contig CP000764_GR.
KEGGbcy:Bcer98_1729.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAA7GPH3. KVGPGNG.

Family and domain databases

HAMAPMF_01670.
[Tree]
InterProIPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
IPR010061. MeMal-semiAld_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PTHR11699:SF27. MMSDH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01722. MMSDH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameIOLA_BACCN
AccessionPrimary (citable) accession number: A7GPH3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: September 11, 2007
Last modified: June 16, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents