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Reviewed, UniProtKB/Swiss-Prot A7GP90 (TYSY_BACCN)

Last modified November 3, 2009. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Thymidylate synthase
      Short name=TS
      Short name=TSase
    EC=2.1.1.45
Gene names
Name: thyA
Ordered Locus Names: Bcer98_1639
OrganismBacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]
Taxonomic identifier315749 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity.

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the thymidylate synthase family. Bacterial-type thyA subfamily.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Cellular componentCytoplasm
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdTMP biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionthymidylate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Thymidylate synthase HAMAP MF_00008
PRO_1000073867

Sites

Active site2001 By similarity

Sequences

Sequence LengthMass (Da)Tools
A7GP90-1 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: CD855B461136241F

FASTA31836,810
        10         20         30         40         50         60 
MKHAEYEYLN LCRHVMEHGT KKEDRTGTGT VSVFGYQMRF DLSKGFPLLT TKRVPFRLVA 

        70         80         90        100        110        120 
SELLWFMKGD TNIRYLLQHN NNIWNEWAFK NWVESDEYKG PDMTNFGLRS QEDEAFKTQY 

       130        140        150        160        170        180 
DEQMEIFKKN VLEDDEFARK YGYLGDVYGK QWRAWKTAAG ETIDQLKDVI EMIKKTPDSR 

       190        200        210        220        230        240 
RLIVSAWNPE DVPNMALPPC HTLFQFYVAD GKLSCQLYQR SGDIFLGIPF NIASYSLLTH 

       250        260        270        280        290        300 
LIAHECGLAV GEFVHTIGDA HIYTNHFEQV KKQLAREPRP FPTLKLNSDV KSVFDFEMGD 

       310 
LTIEGYDPHP AIKAPVAV 

« Hide

References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CP000764 Genomic DNA. Translation: ABS21948.1.
RefSeqYP_001374943.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA7GP90.

Genome annotation databases

GeneID5347186.
GenomeReviewsGene locus Bcer98_1639 in contig CP000764_GR.
KEGGbcy:Bcer98_1639.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMALGPVYGH.

Family and domain databases

HAMAPMF_00008.
[Tree]
InterProIPR000398. Thymidylat_synth_C.
[Graphical view]
Gene3DG3DSA:3.30.572.10. Thymidylat_synth_C. 2 hits.
PANTHERPTHR11549:SF2. Thymidylat_synth_C. 1 hit.
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
ProDomPD001180. Thymidylat_synth. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR03284. thym_sym. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYSY_BACCN
AccessionPrimary (citable) accession number: A7GP90
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: November 3, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents