A7GP45 (A7GP45_BACCN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	fhs HAMAP MF_01543
Ordered Locus Names:	Bcer98_1593

Organism

Bacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP] EMBL ABS21903.1

Taxonomic identifier

315749 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	583 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543
Ligand	ATP-binding HAMAP MF_01543 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 EMBL ABS21903.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	92 – 99	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	A7GP45 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 2AB4C4A5DB515671	FASTA	583	62,903
	10 20 30 40 50 60 MQKIQKTDTI WSEPIKGGLG YMTTTTTVKS DIEIAQEARM KKIQDIAAEL DILEEELEPY 70 80 90 100 110 120 GHYKGKLSLD IFKRLQTKTE GKVVLVTAIN PTPAGEGKST VTVGLGQAFH KIGKKAVIAL 130 140 150 160 170 180 REPSLGPTMG LKGGAAGGGY SQVVPMEDIN LHFTGDIHAI TTANNALAAF IDNHIQQGNA 190 200 210 220 230 240 LQIDTRKIVW KRCVDLNDRA LRNVVIGLGG PVQGVPREDG FDITVASEIM AVFCLATDIQ 250 260 270 280 290 300 DLKARLSRIV VAYNFENQPV TVKDLGVEGA LTLLLKDALK PNLVQTLENT PAIIHGGPFA 310 320 330 340 350 360 NIAHGCNSVI ATTMAAKLGD YVITEAGFGA DLGAEKFLDI KARAAGIKPE AVVIVATIRA 370 380 390 400 410 420 LKMHGGVAKD QLKEENVDAL AKGMENLQKH VETIQSFGVP FVIAINKFIT DTDAEVAYLQ 430 440 450 460 470 480 KWCNERGYEV SLTEVWEKGG QGGVDLAEKV LKVIEKGENK YAPLYDLNAS LEEKIRTIAQ 490 500 510 520 530 540 KVYGAKDIEF APKARKQLAQ FEGEGWGNLP VCMAKTQYSL SDDATKLGRP SDFIVTIREL 550 560 570 580 KPSIGAGFIV ALTGTMLTMP GLPKQPAALQ MDVNEDGKAV GLF

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000764 Genomic DNA. Translation: ABS21903.1.
RefSeq	YP_001374898.1. NC_009674.1.
3D structure databases
ProteinModelPortal	A7GP45.
SMR	A7GP45. Positions 31-581.
ModBase	Search...
Protein-protein interaction databases
STRING	A7GP45.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000039712; EBBACP00000038763; EBBACG00000039703.
GeneID	5345645.
GenomeReviews	Gene locus Bcer98_1593 in contig CP000764_GR.
KEGG	bcy:Bcer98_1593.
PATRIC	18931662. VBIBacCyt128034_1675.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
GeneTree	EBGT00050000004414.
HOGENOM	HBG677721.
OMA	EIMAVLC.
ProtClustDB	PRK13505.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A7GP45_BACCN

Accession

Primary (citable) accession number: A7GP45

Entry history

Integrated into UniProtKB/TrEMBL:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)