Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot A7GNY4 (NAMA_BACCN)

Last modified November 25, 2008. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    NADPH dehydrogenase
    EC=1.6.99.1
Alternative name(s):
    Xenobiotic reductase
Gene names
Name: namA
Ordered Locus Names: Bcer98_1529
OrganismBacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]
Taxonomic identifier315749 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Hide | Top

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Function

Catalyzes the reduction of the double bond of an array of alpha, beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes By similarity.

Catalytic activity

NADPH + acceptor = NADP(+) + reduced acceptor.

Cofactor

FMN By similarity.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.

Hide | Top

Ontologies

Keywords

   LigandFMN
Flavoprotein
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionFMN binding

Inferred from electronic annotation. Source: InterPro

NADPH dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346NADPH dehydrogenase
PRO_0000323520

Regions

Nucleotide binding23 – 275FMN By similarity

Sites

Binding site281Substrate By similarity
Binding site1641Substrate By similarity
Binding site1671Substrate By similarity
Binding site2151FMN By similarity
Binding site3081FMN By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
A7GNY4-1 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 65ED5C561EBC61F0

FASTA34638,479
        10         20         30         40         50         60 
MNTQLFSPFT IQNVTLKNRI VMSPMCMYSS ENEDGKVTNF HLIHYGTRAM GQVGLVMLEA 

        70         80         90        100        110        120 
TAVAAEGRIS NKDLGIWNDE HIEGLQKTVS FIKEHDSKAA IQLAHAGRKA ELHTDPVAPS 

       130        140        150        160        170        180 
AIPFNDKMKV PVAMSKEQIQ DTITAFQKAA IRSKQAGFDV IELHGAHGYL INEFLSPLSN 

       190        200        210        220        230        240 
KRTDEYGGTA ENRYRFLREI IHAVKEVWEG PLFVRISADD YHPEGLTVND YVQFAKWMKE 

       250        260        270        280        290        300 
QGVDLIDCSS GAVVPAHIDV YPGYQVKYAK HLKEHAQIAT GAVGLITSGV QAEQILVNSE 

       310        320        330        340 
ADLIFVGREL LRNPYFPRTA ANELGFELKD PHQYSRAPGK IANTSK

« Hide

Hide | Top

References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Hide | Top

Cross-references

Sequence databases

CP000764 Genomic DNA. Translation: ABS21842.1.
RefSeqYP_001374837.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID5345792.
GenomeReviewsGene locus Bcer98_1529 in contig CP000764_GR.
KEGGbcy:Bcer98_1529.

Organism-specific databases

CMRSearch...

Family and domain databases

HAMAPMF_01614.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF00724. Oxidored_FMN. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameNAMA_BACCN
AccessionPrimary (citable) accession number: A7GNY4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: September 11, 2007
Last modified: November 25, 2008
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents