A7GNS8 (DEOC_BACCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	Bcer98_1469

Organism

Bacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]

Taxonomic identifier

315749 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Deoxyribose-phosphate aldolase HAMAP MF_00114		PRO_1000076026
Sites
	Active site	152	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	181	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7GNS8 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 3B9EE85833AB74F3	FASTA	223	23,676
	10 20 30 40 50 60 MNIAKLIDHT VLKPNSKKED VMKVIEEAKK YNFASVCINP TWVKLAAEEL AGHDVDVCTV 70 80 90 100 110 120 IGFPLGANTT ETKVFETKDV IAKGATEVDM VINVGALKDG DDEFVEKDIR EVVQAAKGKA 130 140 150 160 170 180 LVKVIIETCL LTDEEKVRAC ELSVKAGADF VKTSTGFSTG GATAEDIALM RKTVGPNVGV 190 200 210 220 KASGGVRTRE DAEKMIEAGA SRIGASASVA IVLNDEKGAT DNY

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NVH 391-98.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000764 Genomic DNA. Translation: ABS21786.1.
RefSeq	YP_001374781.1. NC_009674.1.
3D structure databases
ProteinModelPortal	A7GNS8.
SMR	A7GNS8. Positions 2-215.
ModBase	Search...
Protein-protein interaction databases
STRING	A7GNS8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000038771; EBBACP00000037822; EBBACG00000038762.
GeneID	5344938.
GenomeReviews	Gene locus Bcer98_1469 in contig CP000764_GR.
KEGG	bcy:Bcer98_1469.
PATRIC	18931406. VBIBacCyt128034_1547.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0274.
GeneTree	EBGT00050000000908.
HOGENOM	HBG636421.
OMA	IDHTNLK.
ProtClustDB	PRK00507.
Enzyme and pathway databases
BioCyc	BCER315749:BCER98_1469-MONOMER.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR022979. Deoxyribose_phosphate_aldo_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_BACCN

Accession

Primary (citable) accession number: A7GNS8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	September 11, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program