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Protein

Aspartokinase

Gene

Bcer98_1430

Organism
Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-aspartate = ADP + 4-phospho-L-aspartate.UniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Aspartokinase (Bcer98_1430), Aspartokinase (Bcer98_2452)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. 4-hydroxy-tetrahydrodipicolinate synthase (dapA), 4-hydroxy-tetrahydrodipicolinate synthase (dapA)
  4. 4-hydroxy-tetrahydrodipicolinate reductase (dapB)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-homoserine from L-aspartate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Aspartokinase (Bcer98_1430), Aspartokinase (Bcer98_2452)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (Bcer98_1496), Homoserine dehydrogenase (Bcer98_3923)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (Bcer98_1430), Aspartokinase (Bcer98_2452)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (Bcer98_1496), Homoserine dehydrogenase (Bcer98_3923)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (Bcer98_1497)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processAmino-acid biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciBCYT315749:GH2A-1488-MONOMER
UniPathwayiUPA00034; UER00015
UPA00050; UER00461
UPA00051; UER00462

Names & Taxonomyi

Protein namesi
Recommended name:
AspartokinaseUniRule annotation (EC:2.7.2.4UniRule annotation)
Gene namesi
Ordered Locus Names:Bcer98_1430Imported
OrganismiBacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)Imported
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002300 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi315749.Bcer98_1430

Structurei

3D structure databases

ProteinModelPortaliA7GNP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini262 – 336ACTInterPro annotationAdd BLAST75
Domaini342 – 410ACTInterPro annotationAdd BLAST69

Sequence similaritiesi

Belongs to the aspartokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CFH Bacteria
COG0527 LUCA
HOGENOMiHOG000293093
KOiK00928
OMAiDFNLRMI
OrthoDBiPOG091H0223

Family and domain databases

Gene3Di3.40.1160.101 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR002912 ACT_dom
IPR001048 Asp/Glu/Uridylate_kinase
IPR005260 Asp_kin_monofn
IPR001341 Asp_kinase
IPR018042 Aspartate_kinase_CS
IPR027795 CASTOR_ACT_dom
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PF01842 ACT, 1 hit
PF13840 ACT_7, 1 hit
PIRSFiPIRSF000726 Asp_kin, 2 hits
SUPFAMiSSF53633 SSF53633, 1 hit
TIGRFAMsiTIGR00656 asp_kin_monofn, 1 hit
TIGR00657 asp_kinases, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 2 hits
PS00324 ASPARTOKINASE, 1 hit

Sequencei

Sequence statusi: Complete.

A7GNP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METIVQKFGG TSVGNIQRIQ HVANLMIEEY EKGHNVVTVV SAMGKSTDKL
60 70 80 90 100
VALATSITEN PSKRELDMLL TTGEQVTISL LTMALQTKGY QAISLTGWQA
110 120 130 140 150
GITTEPVHGN ARITDIHTER IQSYLQEGTI VIVAGFQGLS EEKEITTLGR
160 170 180 190 200
GGSDTTAVAL AAALKAKKCD IYTDVTGVYT TDPRVVNNAY KLDEISYDEM
210 220 230 240 250
LELANLGAGV LHPRAVEFAK NHNVVLEVRS SMEQENGTIV RGECNMEQQS
260 270 280 290 300
IVKGIAFEDN ITRVTIKGLE HDSLSTIFST LAEAHINVDI IIQSITNEGT
310 320 330 340 350
VHLSFSIHSN DLRETLEALK QNQETLHYES VEYENHLAKV SIVGSGMVSN
360 370 380 390 400
PGVAAHMFST LKEENIHVKM VSTSEIKISV VIDRLHLVDG VEALHQAFMT
410
KVEPLVQMNK
Length:410
Mass (Da):44,896
Last modified:September 11, 2007 - v1
Checksum:i5461CB86FF987D70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA Translation: ABS21749.1
RefSeqiWP_012093923.1, NC_009674.1

Genome annotation databases

EnsemblBacteriaiABS21749; ABS21749; Bcer98_1430
GeneIDi33896770
KEGGibcy:Bcer98_1430

Similar proteinsi

Entry informationi

Entry nameiA7GNP1_BACCN
AccessioniPrimary (citable) accession number: A7GNP1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported