Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aspartokinase

Gene

Bcer98_1430

Organism
Bacillus cereus subsp. cytotoxis (strain NVH 391-98)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-aspartate = ADP + 4-phospho-L-aspartate.UniRule annotation

Pathway: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Aspartokinase (Bcer98_1430), Aspartokinase (Bcer98_2452)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. 4-hydroxy-tetrahydrodipicolinate synthase (dapA), 4-hydroxy-tetrahydrodipicolinate synthase (dapA)
  4. 4-hydroxy-tetrahydrodipicolinate reductase (dapB)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Pathway: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-homoserine from L-aspartate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Aspartokinase (Bcer98_1430), Aspartokinase (Bcer98_2452)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (Bcer98_1496), Homoserine dehydrogenase (Bcer98_3923)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathway: L-threonine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (Bcer98_1430), Aspartokinase (Bcer98_2452)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (Bcer98_1496), Homoserine dehydrogenase (Bcer98_3923)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (Bcer98_1497)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciBCYT315749:GH2A-1543-MONOMER.
UniPathwayiUPA00034; UER00015.
UPA00050; UER00461.
UPA00051; UER00462.

Names & Taxonomyi

Protein namesi
Recommended name:
AspartokinaseUniRule annotation (EC:2.7.2.4UniRule annotation)
Gene namesi
Ordered Locus Names:Bcer98_1430Imported
OrganismiBacillus cereus subsp. cytotoxis (strain NVH 391-98)Imported
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002300 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi315749.Bcer98_1430.

Structurei

3D structure databases

ProteinModelPortaliA7GNP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aspartokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0527.
HOGENOMiHOG000293093.
KOiK00928.
OMAiINIMMIS.
OrthoDBiEOG6NSGHC.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
InterProiIPR002912. ACT_dom.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR005260. Asp_kin_monofn.
IPR001341. Asp_kinase_dom.
IPR018042. Aspartate_kinase_CS.
IPR027795. GATS-like_ACT_dom.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF01842. ACT. 1 hit.
PF13840. ACT_7. 1 hit.
[Graphical view]
PIRSFiPIRSF000726. Asp_kin. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00656. asp_kin_monofn. 1 hit.
TIGR00657. asp_kinases. 1 hit.
PROSITEiPS51671. ACT. 2 hits.
PS00324. ASPARTOKINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7GNP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METIVQKFGG TSVGNIQRIQ HVANLMIEEY EKGHNVVTVV SAMGKSTDKL
60 70 80 90 100
VALATSITEN PSKRELDMLL TTGEQVTISL LTMALQTKGY QAISLTGWQA
110 120 130 140 150
GITTEPVHGN ARITDIHTER IQSYLQEGTI VIVAGFQGLS EEKEITTLGR
160 170 180 190 200
GGSDTTAVAL AAALKAKKCD IYTDVTGVYT TDPRVVNNAY KLDEISYDEM
210 220 230 240 250
LELANLGAGV LHPRAVEFAK NHNVVLEVRS SMEQENGTIV RGECNMEQQS
260 270 280 290 300
IVKGIAFEDN ITRVTIKGLE HDSLSTIFST LAEAHINVDI IIQSITNEGT
310 320 330 340 350
VHLSFSIHSN DLRETLEALK QNQETLHYES VEYENHLAKV SIVGSGMVSN
360 370 380 390 400
PGVAAHMFST LKEENIHVKM VSTSEIKISV VIDRLHLVDG VEALHQAFMT
410
KVEPLVQMNK
Length:410
Mass (Da):44,896
Last modified:September 11, 2007 - v1
Checksum:i5461CB86FF987D70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA. Translation: ABS21749.1.
RefSeqiWP_012093923.1. NC_009674.1.
YP_001374744.1. NC_009674.1.

Genome annotation databases

EnsemblBacteriaiABS21749; ABS21749; Bcer98_1430.
KEGGibcy:Bcer98_1430.
PATRICi18931322. VBIBacCyt128034_1505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA. Translation: ABS21749.1.
RefSeqiWP_012093923.1. NC_009674.1.
YP_001374744.1. NC_009674.1.

3D structure databases

ProteinModelPortaliA7GNP1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315749.Bcer98_1430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS21749; ABS21749; Bcer98_1430.
KEGGibcy:Bcer98_1430.
PATRICi18931322. VBIBacCyt128034_1505.

Phylogenomic databases

eggNOGiCOG0527.
HOGENOMiHOG000293093.
KOiK00928.
OMAiINIMMIS.
OrthoDBiEOG6NSGHC.

Enzyme and pathway databases

UniPathwayiUPA00034; UER00015.
UPA00050; UER00461.
UPA00051; UER00462.
BioCyciBCYT315749:GH2A-1543-MONOMER.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
InterProiIPR002912. ACT_dom.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR005260. Asp_kin_monofn.
IPR001341. Asp_kinase_dom.
IPR018042. Aspartate_kinase_CS.
IPR027795. GATS-like_ACT_dom.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF01842. ACT. 1 hit.
PF13840. ACT_7. 1 hit.
[Graphical view]
PIRSFiPIRSF000726. Asp_kin. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00656. asp_kin_monofn. 1 hit.
TIGR00657. asp_kinases. 1 hit.
PROSITEiPS51671. ACT. 2 hits.
PS00324. ASPARTOKINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NVH 391-98Imported.

Entry informationi

Entry nameiA7GNP1_BACCN
AccessioniPrimary (citable) accession number: A7GNP1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 27, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.