A7GN70 (DAPB_BACCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	Bcer98_1256

Organism

Bacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]

Taxonomic identifier

315749 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_1000075670

Sequences

	Sequence		Length	Mass (Da)
	A7GN70 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: E7F9C01CBB262D7B	FASTA	266	29,429
	10 20 30 40 50 60 MKDIKVIIAG PRGRMGHEAV LLMERTPHFQ FVAAVDYKHG GEKISDLPGM PALDVPIYED 70 80 90 100 110 120 LHTCLDEIEA DVLLDLTTPE VGKKHVTLAV EHGLRSVIGT TGFTEEELQH LTNIAKEKEV 130 140 150 160 170 180 GTIIAPNFAI GAVLMMKFSQ MAAKYFQDVE IIELHHDQKL DAPSGTAVKT VDLIRQHREP 190 200 210 220 230 240 KQQGHPNETE QLKGVRGANV DGIHIHSVRL PGLIAHQEVL FGGDGQMLTV RHDSFNRASF 250 260 MSGVKLSIET VMNLDHLVYG LENIMD

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NVH 391-98.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000764 Genomic DNA. Translation: ABS21578.1.
RefSeq	YP_001374573.1. NC_009674.1.
3D structure databases
ProteinModelPortal	A7GN70.
ModBase	Search...
Protein-protein interaction databases
STRING	A7GN70.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000039310; EBBACP00000038361; EBBACG00000039301.
GeneID	5345960.
GenomeReviews	Gene locus Bcer98_1256 in contig CP000764_GR.
KEGG	bcy:Bcer98_1256.
PATRIC	18930966. VBIBacCyt128034_1327.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0289.
GeneTree	EBGT00050000002586.
HOGENOM	HBG594002.
OMA	DEIGIHA.
ProtClustDB	PRK00048.
Enzyme and pathway databases
BioCyc	BCER315749:BCER98_1256-MONOMER.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_BACCN

Accession

Primary (citable) accession number: A7GN70

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	September 11, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program