Reviewed, UniProtKB/Swiss-Prot A7GN56 (AROA_BACCN)

Names and origin

Protein names

Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase
    EC=2.5.1.19
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase
      Short name=EPSP synthase
      Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Bcer98_1242

Organism

Bacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]

Taxonomic identifier

315749 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 424	424	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000325331

Sequences

	Sequence		Length	Mass (Da)
	A7GN56-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 20F3B5531C315EBC	FASTA	424	45,228
	10 20 30 40 50 60 MANIRREKGL NGTIAIPGDK SISHRAVMFG AIAEGTTKVS NFLLGEDCLS TIACFRKLGV 70 80 90 100 110 120 KIDQSGNDVT IYGKGLTGLQ EPKEVLDVGN SGTTIRLMLG ILANVPFHCT IIGDDSIGKR 130 140 150 160 170 180 PMKRVTDPLR EMNAQIDGRE DGQYTPLSIR GGNIKGIHYD SPVASAQVKS AILLAGLKGE 190 200 210 220 230 240 GVTTVTEPLQ SRDHTERMLR AFGCTVEVTG QTVSLRGGQS LIGTEIEVPG DISSAAFFLV 250 260 270 280 290 300 AGAIVPNSKI VLKNVGLNPT RTGIIDVLQK MGAILSVDHV RNEEFEPCGD ITIETSKLQG 310 320 330 340 350 360 IEIGGSLIPR LIDEIPIIAL LATQATGTTV IKDAEELKVK ETNRIDTVVQ ELKKLGVKIE 370 380 390 400 410 420 ATSDGMIIYG NQKLQGGIVD SHGDHRIGMM LAIASCIADG EVEIQRSDAV SVSYPNFFDQ LASL

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000764 Genomic DNA. Translation: ABS21564.1.
RefSeq	YP_001374559.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7GN56.
Genome annotation databases
GeneID	5345185.
GenomeReviews	Gene locus Bcer98_1242 in contig CP000764_GR.
KEGG	bcy:Bcer98_1242.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	DPLELMG.
Family and domain databases
HAMAP	MF_00210. [Tree]
InterPro	IPR016228. EPSP_synthase. IPR001986. EPSP_synthase_core. IPR006264. EPSP_synthase_subgroup. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_BACCN

Accession

Primary (citable) accession number: A7GN56

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	September 11, 2007
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)