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A7GN54 (AROB_BACCN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:Bcer98_1240
OrganismBacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]
Taxonomic identifier315749 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3693693-dehydroquinate synthase HAMAP MF_00110
PRO_1000094457

Sequences

Sequence LengthMass (Da)Tools
A7GN54 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: B8EB560FAEE1FD84

FASTA36941,301
        10         20         30         40         50         60 
MESIHIQTTS KKYDVYVGKH VLSSLTEVVQ RMKPAVSNVM IISDESVATL HLQKVKEALQ 

        70         80         90        100        110        120 
IKQDVFSFVI PSGEKEKSFE NFYAVHTAAL ENKLDRNSLI IALGGGMIGD LAGFVAATFM 

       130        140        150        160        170        180 
RGIRFVQVPT TLLAHDSAVG GKVAINHPLG KNMIGAFHQP EAVLYHTPFL DSLPEKEWRS 

       190        200        210        220        230        240 
GFAEVIKHAL IGDVELYHWL KNNVTTLADL RDDKLVYVLK RAIPVKAKIV AQDETEKGVR 

       250        260        270        280        290        300 
AHLNFGHTLG HALEKESGYG NITHGDGVAI GMLFAIFLSE QMYKIDLRYK ELKQWFLQYG 

       310        320        330        340        350        360 
YPSIPRHLKV DRLVNVMKQD KKANAGTIRM VLMQEYGGVH VVSISDKTVH TSLEAFQKDM 


VLGEEMNFE

« Hide

References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NVH 391-98.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000764 Genomic DNA. Translation: ABS21562.1.
RefSeqYP_001374557.1. NC_009674.1.

3D structure databases

ProteinModelPortalA7GN54.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7GN54.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000036570; EBBACP00000035621; EBBACG00000036561.
GeneID5345175.
GenomeReviewsGene locus Bcer98_1240 in contig CP000764_GR.
KEGGbcy:Bcer98_1240.
PATRIC18930934. VBIBacCyt128034_1311.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
GeneTreeEBGT00050000002325.
HOGENOMHBG632303.
OMAGTFTQPD.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycBCER315749:BCER98_1240-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_BACCN
AccessionPrimary (citable) accession number: A7GN54
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 11, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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