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A7GN53 (AROC_BACCN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:Bcer98_1239
OrganismBacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]
Taxonomic identifier315749 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Chorismate synthase HAMAP MF_00300
PRO_1000078984

Sequences

Sequence LengthMass (Da)Tools
A7GN53 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 3C8BB20A49079529

FASTA39042,382
        10         20         30         40         50         60 
MRYITAGESH GPQLTTILEG IPAGLPLVAD DINAELARRQ KGYGRGRRMQ IEKDQVQIVS 

        70         80         90        100        110        120 
GVRHGQTIGA PIALIVENKD FAHWTKIMGA APLTEQEKKE MKRQITRPRP GHADLNGAIK 

       130        140        150        160        170        180 
YGHRDMRNVL ERSSARETTV RVAAGAVAKK VLAELGIKVA GHVIEIGGVR AEQTTYETIE 

       190        200        210        220        230        240 
QLQEITEASP VRCLDGEAGK KMMQAIDDAK ASGDSIGGIV EVIVEGMPIG VGSYVHYDRK 

       250        260        270        280        290        300 
LDAKLAAAVM SINAFKGVEI GIGFEAAHRP GSQVHDEILW NEEEGYTRRT NHAGGLEGGM 

       310        320        330        340        350        360 
TTGMPVVVRG VMKPIPTLYK PLQSVDIETK ESFSASIERS DSCAVPAASV VAEAVVAWEL 

       370        380        390 
ATALVEQFGA DRMDCIRENI ERHNEYAREF

« Hide

References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NVH 391-98.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000764 Genomic DNA. Translation: ABS21561.1.
RefSeqYP_001374556.1. NC_009674.1.

3D structure databases

ProteinModelPortalA7GN53.
SMRA7GN53. Positions 1-390.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7GN53.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000038830; EBBACP00000037881; EBBACG00000038821.
GeneID5345169.
GenomeReviewsGene locus Bcer98_1239 in contig CP000764_GR.
KEGGbcy:Bcer98_1239.
PATRIC18930932. VBIBacCyt128034_1310.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0082.
GeneTreeEBGT00050000002373.
HOGENOMHBG292336.
OMAMLRWLTA.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycBCER315749:BCER98_1239-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_BACCN
AccessionPrimary (citable) accession number: A7GN53
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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