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Protein

Phosphoadenosine phosphosulfate reductase

Gene

cysH

Organism
Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reduction of activated sulfate into sulfite.UniRule annotation

Catalytic activityi

Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.UniRule annotation

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes sulfite from sulfate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase (sat)
  2. Adenylyl-sulfate kinase (cysC)
  3. Phosphoadenosine phosphosulfate reductase (cysH)
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

UniPathwayiUPA00140; UER00206.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoadenosine phosphosulfate reductaseUniRule annotation (EC:1.8.4.8UniRule annotation)
Alternative name(s):
3'-phosphoadenylylsulfate reductaseUniRule annotation
PAPS reductase, thioredoxin dependentUniRule annotation
PAPS sulfotransferaseUniRule annotation
PAdoPS reductaseUniRule annotation
Gene namesi
Name:cysHUniRule annotation
Ordered Locus Names:Bcer98_1143
OrganismiBacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002300 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000750691 – 234Phosphoadenosine phosphosulfate reductaseAdd BLAST234

Interactioni

Protein-protein interaction databases

STRINGi315749.Bcer98_1143.

Structurei

3D structure databases

ProteinModelPortaliA7GMW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PAPS reductase family. CysH subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0175. LUCA.
HOGENOMiHOG000249397.
KOiK00390.
OMAiNPLADWD.
OrthoDBiPOG091H04I4.

Family and domain databases

CDDicd01713. PAPS_reductase. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00063. CysH. 1 hit.
InterProiIPR004511. PAPS/APS_Rdtase.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFiPIRSF000857. PAPS_reductase. 1 hit.
TIGRFAMsiTIGR00434. cysH. 1 hit.

Sequencei

Sequence statusi: Complete.

A7GMW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTYETWEED SMSFSERDET KGALAVLEWA YKQYNDEIVY ACSFGVEGMV
60 70 80 90 100
LLHLINEVNP FAQVVFLDTN VHFCETYALI ERVRQRFPKL NIIEKQPGLT
110 120 130 140 150
LEEQEDKYGK DLWEHNPNLC CKLRKILPLE ELLANKNAWI SGLRREQSET
160 170 180 190 200
RKHTKFINQD HRFQSIKICP LIHWTWKEVW RYVYKHNLPY NPLHDVGYPS
210 220 230
IGCEKCTLPV GKYGSSRDGR WAGSVKTECG LHDQ
Length:234
Mass (Da):27,513
Last modified:September 11, 2007 - v1
Checksum:iC5E3FCCD2A6C873A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA. Translation: ABS21468.1.
RefSeqiWP_011984221.1. NC_009674.1.

Genome annotation databases

EnsemblBacteriaiABS21468; ABS21468; Bcer98_1143.
KEGGibcy:Bcer98_1143.
PATRICi18930744. VBIBacCyt128034_1216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA. Translation: ABS21468.1.
RefSeqiWP_011984221.1. NC_009674.1.

3D structure databases

ProteinModelPortaliA7GMW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315749.Bcer98_1143.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS21468; ABS21468; Bcer98_1143.
KEGGibcy:Bcer98_1143.
PATRICi18930744. VBIBacCyt128034_1216.

Phylogenomic databases

eggNOGiCOG0175. LUCA.
HOGENOMiHOG000249397.
KOiK00390.
OMAiNPLADWD.
OrthoDBiPOG091H04I4.

Enzyme and pathway databases

UniPathwayiUPA00140; UER00206.

Family and domain databases

CDDicd01713. PAPS_reductase. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00063. CysH. 1 hit.
InterProiIPR004511. PAPS/APS_Rdtase.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFiPIRSF000857. PAPS_reductase. 1 hit.
TIGRFAMsiTIGR00434. cysH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCYSH_BACCN
AccessioniPrimary (citable) accession number: A7GMW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: November 30, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.