Reviewed, UniProtKB/Swiss-Prot A7GMD4 (ODO1_BACCN)

Names and origin

Protein names

Recommended name:
    2-oxoglutarate dehydrogenase E1 component
    EC=1.2.4.2
Alternative name(s):
    Alpha-ketoglutarate dehydrogenase

Gene names

Name:	odhA
Ordered Locus Names:	Bcer98_0961

Organism

Bacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]

Taxonomic identifier

315749 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	958 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2).
Cofactor	Thiamine pyrophosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: HAMAP thiamin pyrophosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 958	958	2-oxoglutarate dehydrogenase E1 component		PRO_1000085384

Sequences

	Sequence		Length	Mass (Da)
	A7GMD4-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: C3D676435F9C4694	FASTA	958	107,259
	10 20 30 40 50 60 MTRKNTATNP WAKFHGPNLG YVIEQYDRYM TNEGSVDPEL QELFETFGAP TFQVDVVTGD 70 80 90 100 110 120 NKETNFSPQS TGNIETILKA VQVVENIRSF GHLSAHINPM EEPHDGQSLI ETMMRELNDV 130 140 150 160 170 180 DLKAIPAKTV WPDAPNDVHT ALDAIHRLKD VYTKSLAYEF SHIQDSEERT WLHQMVESNS 190 200 210 220 230 240 LRQPLSNQKR TALLKRLTAV EGFEQFLHKT FVGQKRFSIE GVDMLVPVLD EMIAEGAKAG 250 260 270 280 290 300 VEDVMIGMAH RGRLSVLAHV LEKPYSHMFA EFKHATIQSD DKTNHNAGWT GDVKYHLGRE 310 320 330 340 350 360 QVVGNETVRT RVTLANNPSH LEFVNPVVEG YARAAQENRK KAGYPEQDSS KSFVILVHGD 370 380 390 400 410 420 AAFPGQGIVS ETLNLSRLNA YQTGGTIHII ANNTIGFTTD SYDSRSTRYS SDLAKGFDIP 430 440 450 460 470 480 IVHVNADDPE ACLAAANLAI QYRLRFKKDI LIDLIGYRRY GHNEMDDPAV TQPQVYKKIK 490 500 510 520 530 540 NHPTVRAIYA EQLKAEGVLS SDEVETITQF TQEQLKAEYA QVPPADTSEA AIHVKVPDVV 550 560 570 580 590 600 ARGIQPIDTG LPLETLRAIN EGLLSWPEGF NVYPKVKKIL ERRRTALDAD GKVEWALAES 610 620 630 640 650 660 LAFASILQEG TPIRLTGQDS QRGTFAQRHI VLHDTETNET YSPLHRLPNI NASFSVHNSP 670 680 690 700 710 720 LSEAAVVGFE YGYNVFAPET LVMWEAQYGD FANTAQALFD QYVSSGRAKW GQKSGLVLLL 730 740 750 760 770 780 PHGYEGQGPE HSSARPERFL QLAAENNWTV ANLTSAAQYF HILRRQASIL GTEAVRPLVI 790 800 810 820 830 840 MTPKSLLRHP LTASTGSELS EGCFQPALEQ EKLGTKPTKV KRLIFTTGKM AIDLAAEIES 850 860 870 880 890 900 GKHEYNLDEL HIVRIEQLYP FPAEKVQSII KRFKNLEEII WVQEEPRNMG AWHYMAPILF 910 920 930 940 950 ELAGDKLKTG YIGRPDRSSP SGGDPHAHKA EQELIIAHAL DTNYNFRQDK QEIEVYSN

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000764 Genomic DNA. Translation: ABS21292.1.
RefSeq	YP_001374287.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5346526.
GenomeReviews	Gene locus Bcer98_0961 in contig CP000764_GR.
KEGG	bcy:Bcer98_0961.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_01169. [Tree]
InterPro	IPR011603. 2oxoglutarate_DHase_E1. IPR001017. DHase_E1. IPR005475. Transketo_Cen_R. [Graphical view]
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_BACCN

Accession

Primary (citable) accession number: A7GMD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	September 11, 2007
Last modified:	November 4, 2008
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)