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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

thiamine diphosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandThiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotation
Ordered Locus Names:Bcer98_0961
OrganismiBacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000853841 – 9582-oxoglutarate dehydrogenase E1 componentAdd BLAST958

Proteomic databases

PRIDEiA7GMD4

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi315749.Bcer98_0961

Structurei

3D structure databases

ProteinModelPortaliA7GMD4
SMRiA7GMD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C7P Bacteria
COG0567 LUCA
HOGENOMiHOG000259588
KOiK00164
OMAiIDMVCYR
OrthoDBiPOG091H03SK

Family and domain databases

HAMAPiMF_01169 SucA_OdhA, 1 hit
InterProiView protein in InterPro
IPR011603 2oxoglutarate_DH_E1
IPR023784 2oxoglutarate_DH_E1_bac
IPR001017 DH_E1
IPR031717 KGD_C
IPR029061 THDP-binding
IPR005475 Transketolase-like_Pyr-bd
PANTHERiPTHR23152 PTHR23152, 1 hit
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
PF16870 OxoGdeHyase_C, 1 hit
PF02779 Transket_pyr, 1 hit
PIRSFiPIRSF000157 Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
TIGRFAMsiTIGR00239 2oxo_dh_E1, 1 hit

Sequencei

Sequence statusi: Complete.

A7GMD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRKNTATNP WAKFHGPNLG YVIEQYDRYM TNEGSVDPEL QELFETFGAP
60 70 80 90 100
TFQVDVVTGD NKETNFSPQS TGNIETILKA VQVVENIRSF GHLSAHINPM
110 120 130 140 150
EEPHDGQSLI ETMMRELNDV DLKAIPAKTV WPDAPNDVHT ALDAIHRLKD
160 170 180 190 200
VYTKSLAYEF SHIQDSEERT WLHQMVESNS LRQPLSNQKR TALLKRLTAV
210 220 230 240 250
EGFEQFLHKT FVGQKRFSIE GVDMLVPVLD EMIAEGAKAG VEDVMIGMAH
260 270 280 290 300
RGRLSVLAHV LEKPYSHMFA EFKHATIQSD DKTNHNAGWT GDVKYHLGRE
310 320 330 340 350
QVVGNETVRT RVTLANNPSH LEFVNPVVEG YARAAQENRK KAGYPEQDSS
360 370 380 390 400
KSFVILVHGD AAFPGQGIVS ETLNLSRLNA YQTGGTIHII ANNTIGFTTD
410 420 430 440 450
SYDSRSTRYS SDLAKGFDIP IVHVNADDPE ACLAAANLAI QYRLRFKKDI
460 470 480 490 500
LIDLIGYRRY GHNEMDDPAV TQPQVYKKIK NHPTVRAIYA EQLKAEGVLS
510 520 530 540 550
SDEVETITQF TQEQLKAEYA QVPPADTSEA AIHVKVPDVV ARGIQPIDTG
560 570 580 590 600
LPLETLRAIN EGLLSWPEGF NVYPKVKKIL ERRRTALDAD GKVEWALAES
610 620 630 640 650
LAFASILQEG TPIRLTGQDS QRGTFAQRHI VLHDTETNET YSPLHRLPNI
660 670 680 690 700
NASFSVHNSP LSEAAVVGFE YGYNVFAPET LVMWEAQYGD FANTAQALFD
710 720 730 740 750
QYVSSGRAKW GQKSGLVLLL PHGYEGQGPE HSSARPERFL QLAAENNWTV
760 770 780 790 800
ANLTSAAQYF HILRRQASIL GTEAVRPLVI MTPKSLLRHP LTASTGSELS
810 820 830 840 850
EGCFQPALEQ EKLGTKPTKV KRLIFTTGKM AIDLAAEIES GKHEYNLDEL
860 870 880 890 900
HIVRIEQLYP FPAEKVQSII KRFKNLEEII WVQEEPRNMG AWHYMAPILF
910 920 930 940 950
ELAGDKLKTG YIGRPDRSSP SGGDPHAHKA EQELIIAHAL DTNYNFRQDK

QEIEVYSN
Length:958
Mass (Da):107,259
Last modified:September 11, 2007 - v1
Checksum:iC3D676435F9C4694
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA Translation: ABS21292.1
RefSeqiWP_011984045.1, NC_009674.1

Genome annotation databases

EnsemblBacteriaiABS21292; ABS21292; Bcer98_0961
GeneIDi33896324
KEGGibcy:Bcer98_0961

Entry informationi

Entry nameiODO1_BACCN
AccessioniPrimary (citable) accession number: A7GMD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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