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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Bacillus cereus subsp. cytotoxis (strain NVH 391-98)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

thiamine diphosphateUniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-HAMAP
  2. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBCYT315749:GH2A-1072-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotation
Ordered Locus Names:Bcer98_0961
OrganismiBacillus cereus subsp. cytotoxis (strain NVH 391-98)
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002300 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9589582-oxoglutarate dehydrogenase E1 componentPRO_1000085384Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi315749.Bcer98_0961.

Structurei

3D structure databases

ProteinModelPortaliA7GMD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiEHSNARP.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

A7GMD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRKNTATNP WAKFHGPNLG YVIEQYDRYM TNEGSVDPEL QELFETFGAP
60 70 80 90 100
TFQVDVVTGD NKETNFSPQS TGNIETILKA VQVVENIRSF GHLSAHINPM
110 120 130 140 150
EEPHDGQSLI ETMMRELNDV DLKAIPAKTV WPDAPNDVHT ALDAIHRLKD
160 170 180 190 200
VYTKSLAYEF SHIQDSEERT WLHQMVESNS LRQPLSNQKR TALLKRLTAV
210 220 230 240 250
EGFEQFLHKT FVGQKRFSIE GVDMLVPVLD EMIAEGAKAG VEDVMIGMAH
260 270 280 290 300
RGRLSVLAHV LEKPYSHMFA EFKHATIQSD DKTNHNAGWT GDVKYHLGRE
310 320 330 340 350
QVVGNETVRT RVTLANNPSH LEFVNPVVEG YARAAQENRK KAGYPEQDSS
360 370 380 390 400
KSFVILVHGD AAFPGQGIVS ETLNLSRLNA YQTGGTIHII ANNTIGFTTD
410 420 430 440 450
SYDSRSTRYS SDLAKGFDIP IVHVNADDPE ACLAAANLAI QYRLRFKKDI
460 470 480 490 500
LIDLIGYRRY GHNEMDDPAV TQPQVYKKIK NHPTVRAIYA EQLKAEGVLS
510 520 530 540 550
SDEVETITQF TQEQLKAEYA QVPPADTSEA AIHVKVPDVV ARGIQPIDTG
560 570 580 590 600
LPLETLRAIN EGLLSWPEGF NVYPKVKKIL ERRRTALDAD GKVEWALAES
610 620 630 640 650
LAFASILQEG TPIRLTGQDS QRGTFAQRHI VLHDTETNET YSPLHRLPNI
660 670 680 690 700
NASFSVHNSP LSEAAVVGFE YGYNVFAPET LVMWEAQYGD FANTAQALFD
710 720 730 740 750
QYVSSGRAKW GQKSGLVLLL PHGYEGQGPE HSSARPERFL QLAAENNWTV
760 770 780 790 800
ANLTSAAQYF HILRRQASIL GTEAVRPLVI MTPKSLLRHP LTASTGSELS
810 820 830 840 850
EGCFQPALEQ EKLGTKPTKV KRLIFTTGKM AIDLAAEIES GKHEYNLDEL
860 870 880 890 900
HIVRIEQLYP FPAEKVQSII KRFKNLEEII WVQEEPRNMG AWHYMAPILF
910 920 930 940 950
ELAGDKLKTG YIGRPDRSSP SGGDPHAHKA EQELIIAHAL DTNYNFRQDK

QEIEVYSN
Length:958
Mass (Da):107,259
Last modified:September 11, 2007 - v1
Checksum:iC3D676435F9C4694
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA. Translation: ABS21292.1.
RefSeqiYP_001374287.1. NC_009674.1.

Genome annotation databases

EnsemblBacteriaiABS21292; ABS21292; Bcer98_0961.
KEGGibcy:Bcer98_0961.
PATRICi18930352. VBIBacCyt128034_1021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA. Translation: ABS21292.1.
RefSeqiYP_001374287.1. NC_009674.1.

3D structure databases

ProteinModelPortaliA7GMD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315749.Bcer98_0961.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS21292; ABS21292; Bcer98_0961.
KEGGibcy:Bcer98_0961.
PATRICi18930352. VBIBacCyt128034_1021.

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiEHSNARP.
OrthoDBiEOG6V1M1F.

Enzyme and pathway databases

BioCyciBCYT315749:GH2A-1072-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NVH 391-98.

Entry informationi

Entry nameiODO1_BACCN
AccessioniPrimary (citable) accession number: A7GMD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: April 1, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.