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A7GMD4

- ODO1_BACCN

UniProt

A7GMD4 - ODO1_BACCN

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene
odhA, Bcer98_0961
Organism
Bacillus cereus subsp. cytotoxis (strain NVH 391-98)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBCYT315749:GH2A-1072-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:odhA
Ordered Locus Names:Bcer98_0961
OrganismiBacillus cereus subsp. cytotoxis (strain NVH 391-98)
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002300: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9589582-oxoglutarate dehydrogenase E1 componentUniRule annotationPRO_1000085384Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi315749.Bcer98_0961.

Structurei

3D structure databases

ProteinModelPortaliA7GMD4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiQHAPNKE.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

A7GMD4-1 [UniParc]FASTAAdd to Basket

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MTRKNTATNP WAKFHGPNLG YVIEQYDRYM TNEGSVDPEL QELFETFGAP    50
TFQVDVVTGD NKETNFSPQS TGNIETILKA VQVVENIRSF GHLSAHINPM 100
EEPHDGQSLI ETMMRELNDV DLKAIPAKTV WPDAPNDVHT ALDAIHRLKD 150
VYTKSLAYEF SHIQDSEERT WLHQMVESNS LRQPLSNQKR TALLKRLTAV 200
EGFEQFLHKT FVGQKRFSIE GVDMLVPVLD EMIAEGAKAG VEDVMIGMAH 250
RGRLSVLAHV LEKPYSHMFA EFKHATIQSD DKTNHNAGWT GDVKYHLGRE 300
QVVGNETVRT RVTLANNPSH LEFVNPVVEG YARAAQENRK KAGYPEQDSS 350
KSFVILVHGD AAFPGQGIVS ETLNLSRLNA YQTGGTIHII ANNTIGFTTD 400
SYDSRSTRYS SDLAKGFDIP IVHVNADDPE ACLAAANLAI QYRLRFKKDI 450
LIDLIGYRRY GHNEMDDPAV TQPQVYKKIK NHPTVRAIYA EQLKAEGVLS 500
SDEVETITQF TQEQLKAEYA QVPPADTSEA AIHVKVPDVV ARGIQPIDTG 550
LPLETLRAIN EGLLSWPEGF NVYPKVKKIL ERRRTALDAD GKVEWALAES 600
LAFASILQEG TPIRLTGQDS QRGTFAQRHI VLHDTETNET YSPLHRLPNI 650
NASFSVHNSP LSEAAVVGFE YGYNVFAPET LVMWEAQYGD FANTAQALFD 700
QYVSSGRAKW GQKSGLVLLL PHGYEGQGPE HSSARPERFL QLAAENNWTV 750
ANLTSAAQYF HILRRQASIL GTEAVRPLVI MTPKSLLRHP LTASTGSELS 800
EGCFQPALEQ EKLGTKPTKV KRLIFTTGKM AIDLAAEIES GKHEYNLDEL 850
HIVRIEQLYP FPAEKVQSII KRFKNLEEII WVQEEPRNMG AWHYMAPILF 900
ELAGDKLKTG YIGRPDRSSP SGGDPHAHKA EQELIIAHAL DTNYNFRQDK 950
QEIEVYSN 958
Length:958
Mass (Da):107,259
Last modified:September 11, 2007 - v1
Checksum:iC3D676435F9C4694
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000764 Genomic DNA. Translation: ABS21292.1.
RefSeqiYP_001374287.1. NC_009674.1.

Genome annotation databases

EnsemblBacteriaiABS21292; ABS21292; Bcer98_0961.
GeneIDi5346526.
KEGGibcy:Bcer98_0961.
PATRICi18930352. VBIBacCyt128034_1021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000764 Genomic DNA. Translation: ABS21292.1 .
RefSeqi YP_001374287.1. NC_009674.1.

3D structure databases

ProteinModelPortali A7GMD4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315749.Bcer98_0961.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS21292 ; ABS21292 ; Bcer98_0961 .
GeneIDi 5346526.
KEGGi bcy:Bcer98_0961.
PATRICi 18930352. VBIBacCyt128034_1021.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi QHAPNKE.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci BCYT315749:GH2A-1072-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NVH 391-98.

Entry informationi

Entry nameiODO1_BACCN
AccessioniPrimary (citable) accession number: A7GMD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: June 11, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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