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A7GMD4 (ODO1_BACCN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component

EC=1.2.4.2
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene names
Name:odhA
Ordered Locus Names:Bcer98_0961
OrganismBacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]
Taxonomic identifier315749 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length958 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169

Cofactor

Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01169

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9589582-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169
PRO_1000085384

Sequences

Sequence LengthMass (Da)Tools
A7GMD4 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: C3D676435F9C4694

FASTA958107,259
        10         20         30         40         50         60 
MTRKNTATNP WAKFHGPNLG YVIEQYDRYM TNEGSVDPEL QELFETFGAP TFQVDVVTGD 

        70         80         90        100        110        120 
NKETNFSPQS TGNIETILKA VQVVENIRSF GHLSAHINPM EEPHDGQSLI ETMMRELNDV 

       130        140        150        160        170        180 
DLKAIPAKTV WPDAPNDVHT ALDAIHRLKD VYTKSLAYEF SHIQDSEERT WLHQMVESNS 

       190        200        210        220        230        240 
LRQPLSNQKR TALLKRLTAV EGFEQFLHKT FVGQKRFSIE GVDMLVPVLD EMIAEGAKAG 

       250        260        270        280        290        300 
VEDVMIGMAH RGRLSVLAHV LEKPYSHMFA EFKHATIQSD DKTNHNAGWT GDVKYHLGRE 

       310        320        330        340        350        360 
QVVGNETVRT RVTLANNPSH LEFVNPVVEG YARAAQENRK KAGYPEQDSS KSFVILVHGD 

       370        380        390        400        410        420 
AAFPGQGIVS ETLNLSRLNA YQTGGTIHII ANNTIGFTTD SYDSRSTRYS SDLAKGFDIP 

       430        440        450        460        470        480 
IVHVNADDPE ACLAAANLAI QYRLRFKKDI LIDLIGYRRY GHNEMDDPAV TQPQVYKKIK 

       490        500        510        520        530        540 
NHPTVRAIYA EQLKAEGVLS SDEVETITQF TQEQLKAEYA QVPPADTSEA AIHVKVPDVV 

       550        560        570        580        590        600 
ARGIQPIDTG LPLETLRAIN EGLLSWPEGF NVYPKVKKIL ERRRTALDAD GKVEWALAES 

       610        620        630        640        650        660 
LAFASILQEG TPIRLTGQDS QRGTFAQRHI VLHDTETNET YSPLHRLPNI NASFSVHNSP 

       670        680        690        700        710        720 
LSEAAVVGFE YGYNVFAPET LVMWEAQYGD FANTAQALFD QYVSSGRAKW GQKSGLVLLL 

       730        740        750        760        770        780 
PHGYEGQGPE HSSARPERFL QLAAENNWTV ANLTSAAQYF HILRRQASIL GTEAVRPLVI 

       790        800        810        820        830        840 
MTPKSLLRHP LTASTGSELS EGCFQPALEQ EKLGTKPTKV KRLIFTTGKM AIDLAAEIES 

       850        860        870        880        890        900 
GKHEYNLDEL HIVRIEQLYP FPAEKVQSII KRFKNLEEII WVQEEPRNMG AWHYMAPILF 

       910        920        930        940        950 
ELAGDKLKTG YIGRPDRSSP SGGDPHAHKA EQELIIAHAL DTNYNFRQDK QEIEVYSN 

« Hide

References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NVH 391-98.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000764 Genomic DNA. Translation: ABS21292.1.
RefSeqYP_001374287.1. NC_009674.1.

3D structure databases

ProteinModelPortalA7GMD4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315749.Bcer98_0961.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS21292; ABS21292; Bcer98_0961.
GeneID5346526.
KEGGbcy:Bcer98_0961.
PATRIC18930352. VBIBacCyt128034_1021.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259588.
KOK00164.
OMAQHAPNKE.
OrthoDBEOG6V1M1F.

Enzyme and pathway databases

BioCycBCYT315749:GH2A-1072-MONOMER.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
HAMAPMF_01169. SucA_OdhA.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_BACCN
AccessionPrimary (citable) accession number: A7GMD4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: June 11, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families