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Protein

Malate synthase

Gene

Bcer98_0853

Organism
Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Pathwayi: glyoxylate cycle

This protein is involved in step 2 of the subpathway that synthesizes (S)-malate from isocitrate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Malate synthase (Bcer98_0853)
This subpathway is part of the pathway glyoxylate cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from isocitrate, the pathway glyoxylate cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei163Proton acceptorUniRule annotation1
Active sitei443Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseImported, Transferase
Biological processGlyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Enzyme and pathway databases

BioCyciBCYT315749:GH2A-925-MONOMER
UniPathwayiUPA00703; UER00720

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthaseUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Ordered Locus Names:Bcer98_0853Imported
OrganismiBacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)Imported
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Interactioni

Protein-protein interaction databases

STRINGi315749.Bcer98_0853

Structurei

3D structure databases

ProteinModelPortaliA7GM30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili34 – 54Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the malate synthase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4107R9S Bacteria
COG2225 LUCA
HOGENOMiHOG000238464
KOiK01638
OMAiETAHIRA
OrthoDBiPOG091H05S7

Family and domain databases

CDDicd00727 malate_synt_A, 1 hit
InterProiView protein in InterPro
IPR011076 Malate_synth-like_sf
IPR006252 Malate_synthA
IPR001465 Malate_synthase
IPR019830 Malate_synthase_CS
PANTHERiPTHR42902 PTHR42902, 1 hit
PfamiView protein in Pfam
PF01274 Malate_synthase, 1 hit
PIRSFiPIRSF001363 Malate_synth, 1 hit
SUPFAMiSSF51645 SSF51645, 1 hit
TIGRFAMsiTIGR01344 malate_syn_A, 1 hit
PROSITEiView protein in PROSITE
PS00510 MALATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

A7GM30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTQTSRVTL AGELLPSYNE ILTPEALTFL KELHENFNER RIQLLKKREE
60 70 80 90 100
KQKRIDAGEF PNFLPETAHI RAGNWTIAPL PRDLEDRRVE ITGPVDRKMI
110 120 130 140 150
INALNSGAHL FMADFEDSSS PTWKNIIEGQ INLRDAAKGT ISYKSPSGKE
160 170 180 190 200
YRLGDQTAVL IVRPRGWHLE EKHMQVDGKR MSGSLVDFGL YFFHNAKTLI
210 220 230 240 250
EKGSGPYFYL PKMESYLEAR LWNDVFVFAQ KYVGIPNGTI KATVLLETIH
260 270 280 290 300
AAFEMDEILY ELRDHSAGLN CGRWDYIFSF LKCFRNHKAF LLPDRAQVTM
310 320 330 340 350
TVPFMRAYSL KVIQTCHRRN APAMGGMAAQ IPIKNNPEAN EIAFEKVRVD
360 370 380 390 400
KEREALDGHD GTWVAHPGLV PVAMEVFNHI MKTPNQIFRK REELHVTEKD
410 420 430 440 450
LLEVPMGTIT EEGLRMNISV GIQYIASWLS GRGAAPIYNL MEDAATAEIS
460 470 480 490 500
RAQVWQWIRH EEGKLNDGRK VTFALVEQLK AEELAKIEKE IGKESFEKGR
510 520
FVEATKLFTD LVRKDEFEPF LTLPGYEIL
Length:529
Mass (Da):60,486
Last modified:September 11, 2007 - v1
Checksum:iB0AABD0F6243D38E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA Translation: ABS21188.1
RefSeqiWP_011983942.1, NC_009674.1

Genome annotation databases

EnsemblBacteriaiABS21188; ABS21188; Bcer98_0853
GeneIDi33896218
KEGGibcy:Bcer98_0853

Similar proteinsi

Entry informationi

Entry nameiA7GM30_BACCN
AccessioniPrimary (citable) accession number: A7GM30
Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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