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Protein

Malate synthase

Gene

Bcer98_0853

Organism
Bacillus cereus subsp. cytotoxis (strain NVH 391-98)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei163 – 1631Proton acceptorUniRule annotation
Active sitei443 – 4431Proton donorUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Enzyme and pathway databases

BioCyciBCYT315749:GH2A-964-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthaseUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Ordered Locus Names:Bcer98_0853Imported
OrganismiBacillus cereus subsp. cytotoxis (strain NVH 391-98)Imported
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002300 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi315749.Bcer98_0853.

Structurei

3D structure databases

ProteinModelPortaliA7GM30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the malate synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000238464.
KOiK01638.
OMAiMMINALN.
OrthoDBiEOG69WFFX.

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7GM30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTQTSRVTL AGELLPSYNE ILTPEALTFL KELHENFNER RIQLLKKREE
60 70 80 90 100
KQKRIDAGEF PNFLPETAHI RAGNWTIAPL PRDLEDRRVE ITGPVDRKMI
110 120 130 140 150
INALNSGAHL FMADFEDSSS PTWKNIIEGQ INLRDAAKGT ISYKSPSGKE
160 170 180 190 200
YRLGDQTAVL IVRPRGWHLE EKHMQVDGKR MSGSLVDFGL YFFHNAKTLI
210 220 230 240 250
EKGSGPYFYL PKMESYLEAR LWNDVFVFAQ KYVGIPNGTI KATVLLETIH
260 270 280 290 300
AAFEMDEILY ELRDHSAGLN CGRWDYIFSF LKCFRNHKAF LLPDRAQVTM
310 320 330 340 350
TVPFMRAYSL KVIQTCHRRN APAMGGMAAQ IPIKNNPEAN EIAFEKVRVD
360 370 380 390 400
KEREALDGHD GTWVAHPGLV PVAMEVFNHI MKTPNQIFRK REELHVTEKD
410 420 430 440 450
LLEVPMGTIT EEGLRMNISV GIQYIASWLS GRGAAPIYNL MEDAATAEIS
460 470 480 490 500
RAQVWQWIRH EEGKLNDGRK VTFALVEQLK AEELAKIEKE IGKESFEKGR
510 520
FVEATKLFTD LVRKDEFEPF LTLPGYEIL
Length:529
Mass (Da):60,486
Last modified:September 10, 2007 - v1
Checksum:iB0AABD0F6243D38E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA. Translation: ABS21188.1.
RefSeqiYP_001374183.1. NC_009674.1.

Genome annotation databases

EnsemblBacteriaiABS21188; ABS21188; Bcer98_0853.
KEGGibcy:Bcer98_0853.
PATRICi18930117. VBIBacCyt128034_0904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA. Translation: ABS21188.1.
RefSeqiYP_001374183.1. NC_009674.1.

3D structure databases

ProteinModelPortaliA7GM30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315749.Bcer98_0853.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS21188; ABS21188; Bcer98_0853.
KEGGibcy:Bcer98_0853.
PATRICi18930117. VBIBacCyt128034_0904.

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000238464.
KOiK01638.
OMAiMMINALN.
OrthoDBiEOG69WFFX.

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720.
BioCyciBCYT315749:GH2A-964-MONOMER.

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NVH 391-98Imported.

Entry informationi

Entry nameiA7GM30_BACCN
AccessioniPrimary (citable) accession number: A7GM30
Entry historyi
Integrated into UniProtKB/TrEMBL: September 10, 2007
Last sequence update: September 10, 2007
Last modified: March 31, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.