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A7GM03 (A7GM03_BACCN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase 1 HAMAP MF_00323
EC=4.99.1.1 HAMAP MF_00323
Alternative name(s):
Heme synthase 1 HAMAP MF_00323
Protoheme ferro-lyase 1 HAMAP MF_00323
Gene names
Name:hemH1 HAMAP MF_00323
Ordered Locus Names:Bcer98_0825
OrganismBacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP] EMBL ABS21161.1
Taxonomic identifier315749 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family. HAMAP MF_00323

Ontologies

Keywords
   Biological processHeme biosynthesis HAMAP MF_00323
Porphyrin biosynthesis HAMAP MF_00323
   Cellular componentCytoplasm HAMAP MF_00323
   LigandIron HAMAP MF_00323
Metal-binding HAMAP MF_00323
   Molecular functionLyase HAMAP MF_00323 EMBL ABS21161.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding1821Iron By similarity HAMAP MF_00323
Metal binding2631Iron By similarity HAMAP MF_00323

Sequences

Sequence LengthMass (Da)Tools
A7GM03 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: B154951DCDED5971

FASTA31135,521
        10         20         30         40         50         60 
MKKKIGLLVM AYGTPYKEED IERYYTHIRR GRKPSPEMLQ DLTERYRAIG GISPLAAITL 

        70         80         90        100        110        120 
EQAKRLEQRL NEMQDDVEFH MYLGLKHIEP FIEDAVQAMH RDGIKEAIAL VLAPHYSTFS 

       130        140        150        160        170        180 
VKSYIGRAQE EAAKCEDLTI HGIESWYKEP KFIQYWVDAV KSIYDGMPEE EREKAVLIVS 

       190        200        210        220        230        240 
AHSLPEKIIA LGDPYPEQLS ETAEYIARGA EVPNYAVGWQ SAGNTPDPWI GPDVQDLTKE 

       250        260        270        280        290        300 
LYEKYGYTSF VYAPVGFVAE HLEVLYDNDI ECKIVTDEIG AKYYRPEMPN ASEAFIDCLA 

       310 
DVVLKKQEEV L

« Hide

References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000764 Genomic DNA. Translation: ABS21161.1.
RefSeqYP_001374156.1. NC_009674.1.

3D structure databases

ProteinModelPortalA7GM03.
SMRA7GM03. Positions 1-311.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7GM03.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000039050; EBBACP00000038101; EBBACG00000039041.
GeneID5346330.
GenomeReviewsGene locus Bcer98_0825 in contig CP000764_GR.
KEGGbcy:Bcer98_0825.
PATRIC18930053. VBIBacCyt128034_0872.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
GeneTreeEBGT00050000002085.
HOGENOMHBG697135.
OMACSETIFE.
ProtClustDBPRK12435.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7GM03_BACCN
AccessionPrimary (citable) accession number: A7GM03
Entry history
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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