A7GM02 (DCUP_BACCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	Bcer98_0824

Organism

Bacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]

Taxonomic identifier

315749 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity. HAMAP MF_00218
Subcellular location	Cytoplasm By similarity HAMAP MF_00218.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.
Sequence caution	The sequence ABS21160.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_0000325626
Regions
	Region	27 – 31	5	Substrate binding By similarity
Sites
	Binding site	46	1	Substrate By similarity
	Binding site	76	1	Substrate By similarity
	Binding site	152	1	Substrate By similarity
	Binding site	207	1	Substrate By similarity
	Binding site	320	1	Substrate By similarity
	Site	76	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7GM02 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: 0B66AC5219448E5F	FASTA	348	39,325
	10 20 30 40 50 60 MVRNINETFL KACKGERTDY VPAWYMRQAG RSQPEYRKIK EKYSLFEITH NPELCAYVTK 70 80 90 100 110 120 LPVDQYNVDA AILYKDIMSP LPAIGVDVEI KSGIGPVIEN PIRSMQDVEK LGEIHPEEDV 130 140 150 160 170 180 PYILDTIRLL TAEMLDVPLI GFSGAPFTLA SYMIEGGPSR NYHKTKAFMY AEPKAWFALM 190 200 210 220 230 240 DKLSDMVIAY LKAQIQAGAK AVQVFDSWVG TVNVADYRIF IKPAMERIFA QVREMNVPMI 250 260 270 280 290 300 MHGVGAGHLA NEWNDLPLDV VGLDWRLSIE EARTRGIHKA VQGNMDPSLL LAPWNVIEEH 310 320 330 340 VKGILDQGMK QPGYVFNLGH GVFPEVNPDT LKRLTAFIHE YSKEQLAK

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NVH 391-98.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000764 Genomic DNA. Translation: ABS21160.1. Different initiation.
RefSeq	YP_001374155.1. NC_009674.1.
3D structure databases
ProteinModelPortal	A7GM02.
SMR	A7GM02. Positions 6-345.
ModBase	Search...
Protein-protein interaction databases
STRING	A7GM02.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000039259; EBBACP00000038310; EBBACG00000039250.
GeneID	5346328.
GenomeReviews	Gene locus Bcer98_0824 in contig CP000764_GR.
KEGG	bcy:Bcer98_0824.
PATRIC	18930051. VBIBacCyt128034_0871.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0407.
GeneTree	EBGT00050000000611.
HOGENOM	HBG628392.
ProtClustDB	PRK00115.
Enzyme and pathway databases
BioCyc	BCER315749:BCER98_0824-MONOMER.
Family and domain databases
HAMAP	MF_00218. URO-D. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
KO	K01599.
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
TIGRFAMs	TIGR01464. HemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_BACCN

Accession

Primary (citable) accession number: A7GM02

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	December 14, 2011
This is version 32 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program