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Reviewed, UniProtKB/Swiss-Prot A7GLY7 (GLPK_BACCN)

Last modified November 3, 2009. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glycerol kinase
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase
    Glycerokinase
      Short name=GK
Gene names
Name: glpK
Ordered Locus Names: Bcer98_0807
OrganismBacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]
Taxonomic identifier315749 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

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Protein attributes

Sequence length496 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism By similarity.

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

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Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

glycerol kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 496496Glycerol kinase HAMAP MF_00186
PRO_1000077409

Regions

Nucleotide binding410 – 4145ATP By similarity

Sites

Binding site121Substrate By similarity
Binding site161ATP By similarity
Binding site821Substrate By similarity
Binding site1341Substrate By similarity
Binding site2441Substrate By similarity
Binding site2661ATP By similarity
Binding site3091ATP; via carbonyl oxygen By similarity

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Sequences

Sequence LengthMass (Da)Tools
A7GLY7-1 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: A7EC4F5C7FC6C9FB

FASTA49655,071
        10         20         30         40         50         60 
METYILSLDQ GTTSSRAILF NKKGEIVHSA QKEFTQYFPK PGWVEHNAQE IWGSILAVIA 

        70         80         90        100        110        120 
TCLSEADVKP EQIAGIGITN QRETAVVWEK ATGKPVYNAI VWQSRQTAEI CEELKEKGYG 

       130        140        150        160        170        180 
DMVREKTGLL IDAYFSGTKV KWILDNVEGA REKAERGELL FGTIDTWLVW KLSGGKAHVT 

       190        200        210        220        230        240 
DYSNASRTLM FNIHDLKWDD ELLEILTVPK SMLPEVRPSS EVYGHTVDYH FFSQNVPIAG 

       250        260        270        280        290        300 
VAGDQQAALF GQACFSEGMA KNTYGTGCFM LMNTGETAVN SNHGLLTTIA WGLNGKVNYA 

       310        320        330        340        350        360 
LEGSIFVAGS AIQWLRDGMR MVNDASESEE YASRVESTDG VYVVPAFVGL GTPYWDSEVR 

       370        380        390        400        410        420 
GAVFGVTRGT TKEHFIRATL ESLGYQTRDV LCAMEADSGI ELKTLRVDGG AVKNNFLMQF 

       430        440        450        460        470        480 
QSDMLQVPVE RPMISETTAL GAAYLAGLAV GYWESQEEIK AQWDMDRSFT PEMEKERSEE 

       490 
LYSGWKKAIE ATKAFK

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References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000764 Genomic DNA. Translation: ABS21145.1.
RefSeqYP_001374140.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA7GLY7.

Genome annotation databases

GeneID5346306.
GenomeReviewsGene locus Bcer98_0807 in contig CP000764_GR.
KEGGbcy:Bcer98_0807.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAIAQREFT.

Family and domain databases

HAMAPMF_00186.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGLPK_BACCN
AccessionPrimary (citable) accession number: A7GLY7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents