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A7GKI2

- PUR9_BACCN

UniProt

A7GKI2 - PUR9_BACCN

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Bacillus cereus subsp. cytotoxis (strain NVH 391-98)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciBCYT315749:GH2A-347-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:Bcer98_0277
    OrganismiBacillus cereus subsp. cytotoxis (strain NVH 391-98)
    Taxonomic identifieri315749 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002300: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 511511Bifunctional purine biosynthesis protein PurHPRO_1000076473Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi315749.Bcer98_0277.

    Structurei

    3D structure databases

    ProteinModelPortaliA7GKI2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230372.
    KOiK00602.
    OMAiGIGQADN.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7GKI2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKRALVSVS NKTGVVEFVK GLLEQGIEVI STGGTKKLLE ENGLQVMGIS    50
    EVTGFPEIMD GRVKTLHPNI HGGLLAVRDN EAHVAEMSEL GIQLIDFVVV 100
    NLYPFKETIA KPDVTFADAI ENIDIGGPTM IRSAAKNHKF VSVIVDPADY 150
    DVVLAELKEK GEVTDETKRK LAAKVFRHTA AYDALISNYL TEQMGEESPE 200
    ILTVTFEKKQ DLRYGENPHQ KATFYKAPFA VASSVAYAEQ LHGKELSYNN 250
    INDADAALSI VKEFTEPAVV AVKHMNPCGV GVGTDIHEAY TRAYEADPVS 300
    IFGGIIAANR EIDKRVAEKL HEIFLEIIIA PSFSKEALEV LQSKKNLRLL 350
    TVNIEKTTSA SKKLTSVQGG LLVQEEDTLA LNEETIIIPT KREPTEQEWN 400
    DLKLAWKVVK HVKSNAIVLA KDNMTIGVGA GQMNRVGSAK IAISQAGSKA 450
    QGSALASDAF FPMPDTVEEA AKAGITAIIQ PGGSIRDEDS IKKADEYGIT 500
    MVFTGVRHFK H 511
    Length:511
    Mass (Da):55,681
    Last modified:September 11, 2007 - v1
    Checksum:i6670148C002D0444
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000764 Genomic DNA. Translation: ABS20640.1.
    RefSeqiYP_001373635.1. NC_009674.1.

    Genome annotation databases

    EnsemblBacteriaiABS20640; ABS20640; Bcer98_0277.
    GeneIDi5344707.
    KEGGibcy:Bcer98_0277.
    PATRICi18928826. VBIBacCyt128034_0301.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000764 Genomic DNA. Translation: ABS20640.1 .
    RefSeqi YP_001373635.1. NC_009674.1.

    3D structure databases

    ProteinModelPortali A7GKI2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315749.Bcer98_0277.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS20640 ; ABS20640 ; Bcer98_0277 .
    GeneIDi 5344707.
    KEGGi bcy:Bcer98_0277.
    PATRICi 18928826. VBIBacCyt128034_0301.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230372.
    KOi K00602.
    OMAi GIGQADN.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci BCYT315749:GH2A-347-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NVH 391-98.

    Entry informationi

    Entry nameiPUR9_BACCN
    AccessioniPrimary (citable) accession number: A7GKI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3