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A7GKI0

- PUR5_BACCN

UniProt

A7GKI0 - PUR5_BACCN

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Bacillus cereus subsp. cytotoxis (strain NVH 391-98)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBCYT315749:GH2A-345-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:Bcer98_0275
    OrganismiBacillus cereus subsp. cytotoxis (strain NVH 391-98)
    Taxonomic identifieri315749 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002300: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000083449Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi315749.Bcer98_0275.

    Structurei

    3D structure databases

    ProteinModelPortaliA7GKI0.
    SMRiA7GKI0. Positions 13-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiPRIYGND.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7GKI0-1 [UniParc]FASTAAdd to Basket

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    MANAYKQAGV DIEAGYEAVS RMKKHVQTTM RKEVLGGLGG FGGMFDLSKL    50
    PLEEPVLVSG TDGVGTKLML AFMADKHDTI GIDAVAMCVN DIVVQGAEPL 100
    FFLDYIACGK ADPSKIEHIV KGIAEGCRQA GCSLIGGETA EMPGMYSKEE 150
    YDLAGFTVGI VDKKKIITGH SLDEGHVLIG LASSGIHSNG YSLVRKVLLE 200
    DGQMSLDRIY GRLELPLGEE LLKPTKIYVK PILELLKKYE VYGMAHITGG 250
    GFIENIPRML PKGIGAEIDL GSWNIQPIFS LIQEVGKIEE KEMFNIFNMG 300
    IGMVVAVKEE NAKAVVRLLE EQGEKAYIIG RTVKGSGVAF NGGIDHE 347
    Length:347
    Mass (Da):37,481
    Last modified:September 11, 2007 - v1
    Checksum:i618AFF21DC6455CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000764 Genomic DNA. Translation: ABS20638.1.
    RefSeqiYP_001373633.1. NC_009674.1.

    Genome annotation databases

    EnsemblBacteriaiABS20638; ABS20638; Bcer98_0275.
    GeneIDi5344704.
    KEGGibcy:Bcer98_0275.
    PATRICi18928822. VBIBacCyt128034_0299.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000764 Genomic DNA. Translation: ABS20638.1 .
    RefSeqi YP_001373633.1. NC_009674.1.

    3D structure databases

    ProteinModelPortali A7GKI0.
    SMRi A7GKI0. Positions 13-341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315749.Bcer98_0275.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS20638 ; ABS20638 ; Bcer98_0275 .
    GeneIDi 5344704.
    KEGGi bcy:Bcer98_0275.
    PATRICi 18928822. VBIBacCyt128034_0299.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi PRIYGND.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci BCYT315749:GH2A-345-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NVH 391-98.

    Entry informationi

    Entry nameiPUR5_BACCN
    AccessioniPrimary (citable) accession number: A7GKI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3