Reviewed,
UniProtKB/Swiss-Prot A7GKH8 (PURL_BACCN)
Last modified
November 3, 2009.
Version 19.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Phosphoribosylformylglycinamidine synthase 2 EC=6.3.5.3 Alternative name(s): Phosphoribosylformylglycinamidine synthase II Short name=FGAM synthase II | ||||
| Gene names |
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| Organism | Bacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 315749 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group |
Protein attributes
| Sequence length | 739 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP MF_00420 |
| Pathway | Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP MF_00420 |
| Subunit structure | Heterodimer of two subunits, purQ and purL By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the FGAMS family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | 'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP phosphoribosylformylglycinamidine synthase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 739 | 739 | Phosphoribosylformylglycinamidine synthase 2 HAMAP MF_00420 | PRO_1000080547 | |||||
Regions | |||||||||
| Nucleotide binding | 111 – 122 | 12 | ATP Potential | ||||||
Sequences
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References
| [1] | "Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CP000764 Genomic DNA. Translation: ABS20636.1. | |
| RefSeq | YP_001373631.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A7GKH8. |
Genome annotation databases | |
| GeneID | 5344702. |
| GenomeReviews | Gene locus Bcer98_0273 in contig CP000764_GR. |
| KEGG | bcy:Bcer98_0273. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| OMA | GNCVGVP. |
Family and domain databases | |
| HAMAP | MF_00420. [Tree] |
| InterPro | IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR010074. PRibForGlyAmidine_synth_II. [Graphical view] |
| Pfam | PF00586. AIRS. 2 hits. PF02769. AIRS_C. 2 hits. [Graphical view] |
| TIGRFAMs | TIGR01736. FGAM_synth_II. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PURL_BACCN | ||||||||
| Accession | Primary (citable) accession number: A7GKH8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


