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A7GIH9

- PYRF_CLOBL

UniProt

A7GIH9 - PYRF_CLOBL

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, CLI_3377
Organism
Clostridium botulinum (strain Langeland / NCTC 10281 / Type F)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Proton donor By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCBOT441772:GJIE-3343-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:CLI_3377
OrganismiClostridium botulinum (strain Langeland / NCTC 10281 / Type F)
Taxonomic identifieri441772 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000002410: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_1000066463Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi441772.CLI_3377.

Structurei

3D structure databases

ProteinModelPortaliA7GIH9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245747.
KOiK01591.
OMAiCRTSNAG.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

Sequencei

Sequence statusi: Complete.

A7GIH9-1 [UniParc]FASTAAdd to Basket

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MIIDKLYENV EKKGCVCVGL DTDISYLPKG FLNKFTNIED AIFAFNQRIV    50
DSTFDVSACY KVQIAYYEAM GIKGMILYKK TLEYIRKKGG IVIADIKRGD 100
ISATAKMYAK AHFEGDFESD FITLNPYMGM DTLEPYKDYF KNKEKGVFLL 150
LRTSNEGSKD IQYLDLKDNK KVYNKVGEKI ENIGKEFLGN CGYSSIGAVV 200
GCTAEENNIR KELKHTFFLI PGYGAQGGKA EVAKSYLSEG NGGIVNSSRG 250
ILLAYKKYDE EGKNFEECAR NEVINMKKTL QII 283
Length:283
Mass (Da):31,858
Last modified:September 11, 2007 - v1
Checksum:iC101A05733ED5C69
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000728 Genomic DNA. Translation: ABS39472.1.
RefSeqiYP_001392589.1. NC_009699.1.

Genome annotation databases

EnsemblBacteriaiABS39472; ABS39472; CLI_3377.
GeneIDi5402564.
KEGGicbf:CLI_3377.
PATRICi19429707. VBICloBot15611_3287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000728 Genomic DNA. Translation: ABS39472.1 .
RefSeqi YP_001392589.1. NC_009699.1.

3D structure databases

ProteinModelPortali A7GIH9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 441772.CLI_3377.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS39472 ; ABS39472 ; CLI_3377 .
GeneIDi 5402564.
KEGGi cbf:CLI_3377.
PATRICi 19429707. VBICloBot15611_3287.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245747.
KOi K01591.
OMAi CRTSNAG.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci CBOT441772:GJIE-3343-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Langeland / NCTC 10281 / Type F.

Entry informationi

Entry nameiPYRF_CLOBL
AccessioniPrimary (citable) accession number: A7GIH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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