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A7GH98

- PUR5_CLOBL

UniProt

A7GH98 - PUR5_CLOBL

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Clostridium botulinum (strain Langeland / NCTC 10281 / Type F)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBOT441772:GJIE-2897-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:CLI_2933
    OrganismiClostridium botulinum (strain Langeland / NCTC 10281 / Type F)
    Taxonomic identifieri441772 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000002410: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000046433Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi441772.CLI_2933.

    Structurei

    3D structure databases

    ProteinModelPortaliA7GH98.
    SMRiA7GH98. Positions 17-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229091.
    KOiK01933.
    OMAiTKVMLAQ.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7GH98-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSYKEAGVN IEEGYKSVDL IKKYASKTFT KGVLNNLGSF AGMFELPKYK    50
    NPVLVSGTDG VGTKLDIAFR MKKYNTVGID CVAMCINDIL CHGAKPLFFL 100
    DYIACGKLES EIAAQLVEGV SNGCIQSECA LIGGETAEMP GFYRDGEYDI 150
    AGFAVGIAEK DEIIDGSKIE DGDILIGIAS SGPHSNGYSL IRKLVEDLHK 200
    DFEGNKIGNT LLTPTKIYVK PVMKLLEKYN IKGMAHVTGG GFYENIPRMF 250
    KEDFTAVINK KSYPLPNIFS HLMSLGIEED HMYNTFNMGI GFVLCVNEKD 300
    GENIIKDLIE MGEKGYKIGY VKKGNKSVEL I 331
    Length:331
    Mass (Da):36,349
    Last modified:September 11, 2007 - v1
    Checksum:i1AF6FD9ED0F3D589
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000728 Genomic DNA. Translation: ABS41211.1.
    RefSeqiWP_012100667.1. NC_009699.1.
    YP_001392158.1. NC_009699.1.

    Genome annotation databases

    EnsemblBacteriaiABS41211; ABS41211; CLI_2933.
    GeneIDi5403713.
    KEGGicbf:CLI_2933.
    PATRICi19428821. VBICloBot15611_2852.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000728 Genomic DNA. Translation: ABS41211.1 .
    RefSeqi WP_012100667.1. NC_009699.1.
    YP_001392158.1. NC_009699.1.

    3D structure databases

    ProteinModelPortali A7GH98.
    SMRi A7GH98. Positions 17-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 441772.CLI_2933.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS41211 ; ABS41211 ; CLI_2933 .
    GeneIDi 5403713.
    KEGGi cbf:CLI_2933.
    PATRICi 19428821. VBICloBot15611_2852.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229091.
    KOi K01933.
    OMAi TKVMLAQ.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci CBOT441772:GJIE-2897-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Langeland / NCTC 10281 / Type F.

    Entry informationi

    Entry nameiPUR5_CLOBL
    AccessioniPrimary (citable) accession number: A7GH98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3