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A7GH98

- PUR5_CLOBL

UniProt

A7GH98 - PUR5_CLOBL

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Clostridium botulinum (strain Langeland / NCTC 10281 / Type F)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBOT441772:GJIE-2897-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:CLI_2933
OrganismiClostridium botulinum (strain Langeland / NCTC 10281 / Type F)
Taxonomic identifieri441772 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000002410: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000046433Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi441772.CLI_2933.

Structurei

3D structure databases

ProteinModelPortaliA7GH98.
SMRiA7GH98. Positions 17-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiTKVMLAQ.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A7GH98-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSYKEAGVN IEEGYKSVDL IKKYASKTFT KGVLNNLGSF AGMFELPKYK
60 70 80 90 100
NPVLVSGTDG VGTKLDIAFR MKKYNTVGID CVAMCINDIL CHGAKPLFFL
110 120 130 140 150
DYIACGKLES EIAAQLVEGV SNGCIQSECA LIGGETAEMP GFYRDGEYDI
160 170 180 190 200
AGFAVGIAEK DEIIDGSKIE DGDILIGIAS SGPHSNGYSL IRKLVEDLHK
210 220 230 240 250
DFEGNKIGNT LLTPTKIYVK PVMKLLEKYN IKGMAHVTGG GFYENIPRMF
260 270 280 290 300
KEDFTAVINK KSYPLPNIFS HLMSLGIEED HMYNTFNMGI GFVLCVNEKD
310 320 330
GENIIKDLIE MGEKGYKIGY VKKGNKSVEL I
Length:331
Mass (Da):36,349
Last modified:September 11, 2007 - v1
Checksum:i1AF6FD9ED0F3D589
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000728 Genomic DNA. Translation: ABS41211.1.
RefSeqiYP_001392158.1. NC_009699.1.

Genome annotation databases

EnsemblBacteriaiABS41211; ABS41211; CLI_2933.
GeneIDi5403713.
KEGGicbf:CLI_2933.
PATRICi19428821. VBICloBot15611_2852.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000728 Genomic DNA. Translation: ABS41211.1 .
RefSeqi YP_001392158.1. NC_009699.1.

3D structure databases

ProteinModelPortali A7GH98.
SMRi A7GH98. Positions 17-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 441772.CLI_2933.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS41211 ; ABS41211 ; CLI_2933 .
GeneIDi 5403713.
KEGGi cbf:CLI_2933.
PATRICi 19428821. VBICloBot15611_2852.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi TKVMLAQ.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci CBOT441772:GJIE-2897-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Langeland / NCTC 10281 / Type F.

Entry informationi

Entry nameiPUR5_CLOBL
AccessioniPrimary (citable) accession number: A7GH98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3