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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Clostridium botulinum (strain Langeland / NCTC 10281 / Type F)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciCBOT441772:G1G98-1976-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:CLI_1988
OrganismiClostridium botulinum (strain Langeland / NCTC 10281 / Type F)
Taxonomic identifieri441772 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000002410 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000683201 – 157Peptide methionine sulfoxide reductase MsrAAdd BLAST157

Proteomic databases

PRIDEiA7GEN6

Structurei

3D structure databases

ProteinModelPortaliA7GEN6
SMRiA7GEN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000263863
KOiK07304
OMAiMRQGGDI

Family and domain databases

Gene3Di3.30.1060.10, 1 hit
HAMAPiMF_01401 MsrA, 1 hit
InterProiView protein in InterPro
IPR002569 Met_Sox_Rdtase_MsrA
IPR036509 Met_Sox_Rdtase_MsrA_sf
PfamiView protein in Pfam
PF01625 PMSR, 1 hit
SUPFAMiSSF55068 SSF55068, 1 hit
TIGRFAMsiTIGR00401 msrA, 1 hit

Sequencei

Sequence statusi: Complete.

A7GEN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEIVLAGGC FWGVEEYMSR IKGIVETKVG YANGIKENPS YEEVCSGTTG
60 70 80 90 100
HAEACYIKYD ESIISLEELL NKFWSIIDPT VLNKQGNDRG TQYRTGIFYL
110 120 130 140 150
DEKDLNVIIK SKSQEQKNYR KPIVTEVEPL KCFYEAEEYH QKYLKKNPEG

YCHIHLG
Length:157
Mass (Da):18,117
Last modified:September 11, 2007 - v1
Checksum:iCF04E35FEDF8723B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000728 Genomic DNA Translation: ABS41820.1
RefSeqiWP_012099946.1, NC_009699.1

Genome annotation databases

EnsemblBacteriaiABS41820; ABS41820; CLI_1988
KEGGicbf:CLI_1988

Similar proteinsi

Entry informationi

Entry nameiMSRA_CLOBL
AccessioniPrimary (citable) accession number: A7GEN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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