Reviewed, UniProtKB/Swiss-Prot A7GDP8 (DEOC_CLOBL)

Names and origin

Protein names

Recommended name:
    Deoxyribose-phosphate aldolase
    EC=4.1.2.4
Alternative name(s):
    Phosphodeoxyriboaldolase
      Short name=Deoxyriboaldolase
      Short name=DERA

Gene names

Name:	deoC
Ordered Locus Names:	CLI_1645

Organism

Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) [Complete proteome] [HAMAP]

Taxonomic identifier

441772 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the deoC/fbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Deoxyribose-phosphate aldolase HAMAP MF_00114		PRO_1000057750
Sites
	Active site	151	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	180	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7GDP8-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 48D4820663BFBDCB	FASTA	212	23,032
	10 20 30 40 50 60 MKLSKYIDHT LLKPQATEKD ILKLIEEAKT YDFASVCVNP SWVKLAYENL KDTDVKVCTV 70 80 90 100 110 120 VGFPLGATST ASKVYETKVA IEDGADEIDM VISVGQLKSG NDEYVKEEIK KIVEASKNKL 130 140 150 160 170 180 VKVIIETCLL TEEEKVKACT LSKEAGADYV KTSTGFSTGG AKPEDIKLMR ETVGKDMGVK 190 200 210 ASGGIHTKEE MEAMIENGAT RIGASCGVQL VR

References

[1]	Brinkac L.M., Daugherty S., Dodson R.J., Madupu R., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., White O., Brettin T.S. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000728 Genomic DNA. Translation: ABS39739.1.
RefSeq	YP_001390908.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7GDP8.
Genome annotation databases
GeneID	5404638.
GenomeReviews	Gene locus CLI_1645 in contig CP000728_GR.
KEGG	cbf:CLI_1645.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	AKMIDHT.
Family and domain databases
HAMAP	MF_00114. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. deoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_CLOBL

Accession

Primary (citable) accession number: A7GDP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 11, 2007
Last modified:	November 3, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)