ID   A7GCE4_CLOBL            Unreviewed;       456 AA.
AC   A7GCE4;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   RecName: Full=Aldehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036492};
GN   OrderedLocusNames=CLI_1188 {ECO:0000313|EMBL:ABS40587.1};
OS   Clostridium botulinum (strain Langeland / NCTC 10281 / Type F).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=441772 {ECO:0000313|EMBL:ABS40587.1, ECO:0000313|Proteomes:UP000002410};
RN   [1] {ECO:0000313|Proteomes:UP000002410}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Langeland / NCTC 10281 / Type F
RC   {ECO:0000313|Proteomes:UP000002410};
RA   Brinkac L.M., Daugherty S., Dodson R.J., Madupu R., Brown J.L., Bruce D.,
RA   Detter C., Munk C., Smith L.A., Smith T.J., White O., Brettin T.S.;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|PIRNR:PIRNR036492,
CC       ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CP000728; ABS40587.1; -; Genomic_DNA.
DR   RefSeq; WP_011987997.1; NC_009699.1.
DR   AlphaFoldDB; A7GCE4; -.
DR   KEGG; cbf:CLI_1188; -.
DR   HOGENOM; CLU_005391_3_1_9; -.
DR   Proteomes; UP000002410; Chromosome.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro.
DR   CDD; cd07136; ALDH_YwdH-P39616; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR   PANTHER; PTHR43570; ALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43570:SF16; ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PIRSF; PIRSF036492; ALDH; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|PIRNR:PIRNR036492}.
FT   DOMAIN          8..428
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        210
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036492-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU10007"
FT   ACT_SITE        244
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036492-1"
SQ   SEQUENCE   456 AA;  51644 MW;  4EBE1E5A8607E8A8 CRC64;
     MENIRNILEK QKSFFDKGYT KDINFRIEAL KKLKHNIKIN ENNIFKALKI DLNKSEFETF
     ITEIGIVYDE INGAIKNIKK WSKPKKVKTP ITNFLASSYI YNEPYGVALI MSPWNYPFQL
     IMAPLVGAIS AGNCVLLKPS ELAIETEKII VKIIKDTFSD EYIGVITGGI EESTALLKEK
     FDYIFYTGGI NVGKIVMRAA AEHLTPITLE LGGKSPCIVD KDANIDLAAR RIAWGKFLNA
     GQTCVAPDYL VVHRNIKEKL ISSIENYIVE FFGENTFESE DYPRIINERH FKRLEGYLKE
     GKIVSGGNTD INNLYIEPTI IEGINFENRI MEEEIFGPIF PVIEFEDIDK VIDIVKNNPK
     PLALYYFSEN KEKQEFIIKN ISFGGGCIND TIMHLSTSTL PFGGVGNSGI GGYHGRASFD
     TFSHKKSILK KSNLIDIKIR YAPFKGKINL AKRLFK
//