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A7GAL1

- THIM1_CLOBL

UniProt

A7GAL1 - THIM1_CLOBL

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Protein
Hydroxyethylthiazole kinase 1
Gene
thiM1, CLI_0535
Organism
Clostridium botulinum (strain Langeland / NCTC 10281 / Type F)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421Substrate; via amide nitrogen By similarity
Binding sitei118 – 1181ATP By similarity
Binding sitei164 – 1641ATP By similarity
Binding sitei191 – 1911Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBOT441772:GJIE-514-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase 1 (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase 1
Short name:
TH kinase 1
Short name:
Thz kinase 1
Gene namesi
Name:thiM1
Ordered Locus Names:CLI_0535
OrganismiClostridium botulinum (strain Langeland / NCTC 10281 / Type F)
Taxonomic identifieri441772 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000002410: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Hydroxyethylthiazole kinase 1UniRule annotation
PRO_0000336549Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi441772.CLI_0535.

Structurei

3D structure databases

ProteinModelPortaliA7GAL1.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiNACTQLA.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

A7GAL1-1 [UniParc]FASTAAdd to Basket

« Hide

MKNKNVIQKM REKIPLIHCI TNYVTINDCA NILLSFGASP AMCEAYDEVY    50
DFVSISSALY INLGTLTKEQ ETAAVLASIS AKNHNVPVVI DPVGCPAIKR 100
KVEVINRIAE VGRIDIIKGN IGEIKFLAGM DSETRGVDSL DNGENALNAC 150
TQLAKKYNCI VAATGQKDFV SDGKRGSVIK NGTEMLTKVT GAGCMLGALC 200
AATCANFEDK LVSTTAAILS MNIAGEKAYE KAQLPGSFRI ALIDNIYMIS 250
DEEIWERGNV EWK 263
Length:263
Mass (Da):28,464
Last modified:September 11, 2007 - v1
Checksum:i8F3C24E8D5D034BE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000728 Genomic DNA. Translation: ABS41348.1.
RefSeqiWP_011987460.1. NC_009699.1.
YP_001389821.1. NC_009699.1.

Genome annotation databases

EnsemblBacteriaiABS41348; ABS41348; CLI_0535.
GeneIDi5405245.
KEGGicbf:CLI_0535.
PATRICi19424032. VBICloBot15611_0459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000728 Genomic DNA. Translation: ABS41348.1 .
RefSeqi WP_011987460.1. NC_009699.1.
YP_001389821.1. NC_009699.1.

3D structure databases

ProteinModelPortali A7GAL1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 441772.CLI_0535.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS41348 ; ABS41348 ; CLI_0535 .
GeneIDi 5405245.
KEGGi cbf:CLI_0535.
PATRICi 19424032. VBICloBot15611_0459.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi NACTQLA.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci CBOT441772:GJIE-514-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Langeland / NCTC 10281 / Type F.

Entry informationi

Entry nameiTHIM1_CLOBL
AccessioniPrimary (citable) accession number: A7GAL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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