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A7G9Y0 (PGK_CLOBL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:CLI_0292
OrganismClostridium botulinum (strain Langeland / NCTC 10281 / Type F) [Complete proteome] [HAMAP]
Taxonomic identifier441772 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_1000009608

Regions

Nucleotide binding354 – 3574ATP By similarity
Region23 – 253Substrate binding By similarity
Region61 – 644Substrate binding By similarity

Sites

Binding site381Substrate By similarity
Binding site1221Substrate By similarity
Binding site1551Substrate By similarity
Binding site2061ATP By similarity
Binding site2971ATP; via carbonyl oxygen By similarity
Binding site3281ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A7G9Y0 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: EF719E8CA23238CD

FASTA39842,976
        10         20         30         40         50         60 
MNYNKKSIED IDVKGKKVLV RCDFNVPLNE GKITDENRLV GALPTIKYLM GKGAKIILCS 

        70         80         90        100        110        120 
HMGKPKGEPK KELSLLPVAK RLSEMLNKEV IFADDDNVVG ENAKKAVEDM KDGDVVLLQN 

       130        140        150        160        170        180 
TRYRKEETKN EEVFSKELAS LADVFVNDAF GTAHRAHCST VGVTNYLKEA ACGYLIQKEL 

       190        200        210        220        230        240 
KFLGNAVEKP ERPFVAILGG AKVSDKINVI NNLLDKVDTL IIGGGMGYTF LKAQGYTIGN 

       250        260        270        280        290        300 
SLVEEDKVEY SKEMIDKAKE KGVNLLLPID NVVADKFDKD ASPVVTEDQN IGEGYMGLDI 

       310        320        330        340        350        360 
GPKTAKIYSD AIKSAKTVVW NGPMGVFEFK SFANGTIEVA KAMADSDAVT IIGGGDSAAA 

       370        380        390 
VNILGFGDKM THISTGGGAS LEFLEGKELP GIAALNDK 

« Hide

References

[1]Brinkac L.M., Daugherty S., Dodson R.J., Madupu R., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., White O., Brettin T.S.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Langeland / NCTC 10281 / Type F.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000728 Genomic DNA. Translation: ABS42835.1.
RefSeqYP_001389590.1. NC_009699.1.

3D structure databases

ProteinModelPortalA7G9Y0.
SMRA7G9Y0. Positions 4-398.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING441772.CLI_0292.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS42835; ABS42835; CLI_0292.
GeneID5405290.
KEGGcbf:CLI_0292.
PATRIC19423540. VBICloBot15611_0219.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227108.
KOK00927.
OMAWEALDIG.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

BioCycCBOT441772:GJIE-272-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_CLOBL
AccessionPrimary (citable) accession number: A7G9Y0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways