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A7G9T9

- SYL_CLOBL

UniProt

A7G9T9 - SYL_CLOBL

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Clostridium botulinum (strain Langeland / NCTC 10281 / Type F)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei575 – 5751ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBOT441772:GJIE-229-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:CLI_0249
    OrganismiClostridium botulinum (strain Langeland / NCTC 10281 / Type F)
    Taxonomic identifieri441772 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000002410: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 813813Leucine--tRNA ligasePRO_1000009327Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi441772.CLI_0249.

    Structurei

    3D structure databases

    ProteinModelPortaliA7G9T9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi572 – 5765"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiDKPKYYA.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7G9T9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNYSTKIDE KWQKKWEENS LYKFNNDNLD KKLYVLEMFS YPSGSKLHAG    50
    HWFNYGPVDS WARFKRMQGY NVFQPMGFDA FGLPAENYAI KTGIHPKDST 100
    FKNIETMETQ LKAMGAMFNW ENEVITCSPD YYKWTQWLFL KLYEKGLAYK 150
    KKAPVNWCPS CNTVLANEQV LDGKCERCDS NVDKKNLEQW FLKITDYADE 200
    LLEKLDELDW PEKTKAMQKH WIGKSVGAEV TFNVADSDLS FNVFTTRVDT 250
    LFGVTYVVLA PENDLVDKLT TPENKAEVES YKTQAKNQSD IERQSITREK 300
    TGVFSGSYAI NPINGKKVPI WIGDYVLNTY GTGCVMAVPA HDERDFAFAT 350
    KYNLPIERVI EGGDSLPYTE YGKMVNSGEF DGLFGNKAKE AVISKLESMN 400
    LGRKKINYRL RDWLVSRQRY WGAPIPIIYC EKCGTVEVPI EQLPVELPYN 450
    VEFSPDGKSP LGKCDDFINT TCPKCGGPAK READTLDTFV CSSWYYLRYP 500
    DNNNEKDAFN PELINKMLPV DKYVGGPEHA CMHLLYARFI TKALRDMGYL 550
    NFDEPFLSLT HQGLILGPDG LKMSKSKGNT ISPDDYIKEF GADVFRMYLM 600
    FGFDYTEGGA WSDDAIKSIG KFVDRVERIL ENAREEIKNS KDNKSTMDKD 650
    EKELNYVRHH SIKSITEDID KMQFNTSIAR LMEFTNALSK YLGSDTLRNA 700
    SFLRESIIDF ITLLAPFAPH FAEEQWELIG INSSIFNEKW PEFDPKALIK 750
    DEVEIAVQVN GKIRAKINIY TSSSEDEIKE SALNNDDIKN SIGDKEIKKV 800
    IVIKNRLVNI VAK 813
    Length:813
    Mass (Da):93,072
    Last modified:September 11, 2007 - v1
    Checksum:iA6D241BCDEBEEC0D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000728 Genomic DNA. Translation: ABS39371.1.
    RefSeqiYP_001389549.1. NC_009699.1.

    Genome annotation databases

    EnsemblBacteriaiABS39371; ABS39371; CLI_0249.
    GeneIDi5403523.
    KEGGicbf:CLI_0249.
    PATRICi19423456. VBICloBot15611_0178.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000728 Genomic DNA. Translation: ABS39371.1 .
    RefSeqi YP_001389549.1. NC_009699.1.

    3D structure databases

    ProteinModelPortali A7G9T9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 441772.CLI_0249.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS39371 ; ABS39371 ; CLI_0249 .
    GeneIDi 5403523.
    KEGGi cbf:CLI_0249.
    PATRICi 19423456. VBICloBot15611_0178.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi DKPKYYA.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CBOT441772:GJIE-229-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Langeland / NCTC 10281 / Type F.

    Entry informationi

    Entry nameiSYL_CLOBL
    AccessioniPrimary (citable) accession number: A7G9T9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3