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A7FZ71

- EFTU_CLOB1

UniProt

A7FZ71 - EFTU_CLOB1

Protein

Elongation factor Tu

Gene

tuf1

more
Organism
Clostridium botulinum (strain ATCC 19397 / Type A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 268GTPUniRule annotation
    Nucleotide bindingi81 – 855GTPUniRule annotation
    Nucleotide bindingi136 – 1394GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-HAMAP
    3. translation elongation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Elongation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBOT441770:GH1E-3504-MONOMER.
    CBOT441770:GH1E-3518-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor TuUniRule annotation
    Short name:
    EF-TuUniRule annotation
    Gene namesi
    Name:tuf1UniRule annotation
    Ordered Locus Names:CLB_3539
    AND
    Name:tuf2UniRule annotation
    Ordered Locus Names:CLB_3553
    OrganismiClostridium botulinum (strain ATCC 19397 / Type A)
    Taxonomic identifieri441770 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000006379: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397Elongation factor TuPRO_0000337356Add
    BLAST

    Proteomic databases

    PRIDEiA7FZ71.

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi441770.CLB_3553.

    Structurei

    3D structure databases

    ProteinModelPortaliA7FZ71.
    SMRiA7FZ71. Positions 2-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 206197tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni19 – 268G1By similarity
    Regioni60 – 645G2By similarity
    Regioni81 – 844G3By similarity
    Regioni136 – 1394G4By similarity
    Regioni174 – 1763G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0050.
    HOGENOMiHOG000229290.
    KOiK02358.
    OMAiRITISCE.
    OrthoDBiEOG6R5C6X.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00118_B. EF_Tu_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7FZ71-1 [UniParc]FASTAAdd to Basket

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    MAKAKFERSK PHVNIGTIGH VDHGKTTLTA AITTVLAQKG GASATKYDEI    50
    DKAPEEKERG ITINTSHVEY ETANRHYAHV DCPGHADYVK NMITGAAQMD 100
    GAILVVSAAD GPMPQTREHI LLASRVGVQY IVVFLNKADQ VDDPELIELV 150
    EMEVRELLNE YGFPGDDTPI VVGSALEVLE NQDNAEKTKC IDELMEAIDS 200
    YIPTPERATD QPFLMPVEDV FTITGRGTVA TGRVERGVLH TGDEVELIGM 250
    KQEVSKTVCT GIEMFRKILD EAMAGDNIGA LLRGIQRDEI QRGQVLAKPG 300
    SVTPHKKFVG QVYVLKKEEG GRHTPFFNGY RPQFYFRTTD VTGSINLPEG 350
    VEMVMPGDHI DMAVELITPV AMHENLRFAI REGGRTVGSG VVTTISE 397
    Length:397
    Mass (Da):43,483
    Last modified:September 11, 2007 - v1
    Checksum:i75AD3C5B65D90FA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000726 Genomic DNA. Translation: ABS32526.1.
    CP000726 Genomic DNA. Translation: ABS32980.1.
    RefSeqiYP_001385798.1. NC_009697.1.
    YP_001385812.1. NC_009697.1.

    Genome annotation databases

    EnsemblBacteriaiABS32526; ABS32526; CLB_3539.
    ABS32980; ABS32980; CLB_3553.
    GeneIDi5396973.
    5397314.
    KEGGicba:CLB_3539.
    cba:CLB_3553.
    PATRICi19361622. VBICloBot110701_3415.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000726 Genomic DNA. Translation: ABS32526.1 .
    CP000726 Genomic DNA. Translation: ABS32980.1 .
    RefSeqi YP_001385798.1. NC_009697.1.
    YP_001385812.1. NC_009697.1.

    3D structure databases

    ProteinModelPortali A7FZ71.
    SMRi A7FZ71. Positions 2-397.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 441770.CLB_3553.

    Proteomic databases

    PRIDEi A7FZ71.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS32526 ; ABS32526 ; CLB_3539 .
    ABS32980 ; ABS32980 ; CLB_3553 .
    GeneIDi 5396973.
    5397314.
    KEGGi cba:CLB_3539.
    cba:CLB_3553.
    PATRICi 19361622. VBICloBot110701_3415.

    Phylogenomic databases

    eggNOGi COG0050.
    HOGENOMi HOG000229290.
    KOi K02358.
    OMAi RITISCE.
    OrthoDBi EOG6R5C6X.

    Enzyme and pathway databases

    BioCyci CBOT441770:GH1E-3504-MONOMER.
    CBOT441770:GH1E-3518-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00118_B. EF_Tu_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
      Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
      PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19397 / Type A.

    Entry informationi

    Entry nameiEFTU_CLOB1
    AccessioniPrimary (citable) accession number: A7FZ71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3