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A7FYM5

- G6PI_CLOB1

UniProt

A7FYM5 - G6PI_CLOB1

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Clostridium botulinum (strain ATCC 19397 / Type A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei291 – 2911Proton donorUniRule annotation
    Active sitei312 – 3121UniRule annotation
    Active sitei426 – 4261UniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciCBOT441770:GH1E-3300-MONOMER.
    UniPathwayiUPA00109; UER00181.
    UPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
    Short name:
    GPIUniRule annotation
    Alternative name(s):
    Phosphoglucose isomeraseUniRule annotation
    Short name:
    PGIUniRule annotation
    Phosphohexose isomeraseUniRule annotation
    Short name:
    PHIUniRule annotation
    Gene namesi
    Name:pgiUniRule annotation
    Ordered Locus Names:CLB_3335
    OrganismiClostridium botulinum (strain ATCC 19397 / Type A)
    Taxonomic identifieri441770 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000006379: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450Glucose-6-phosphate isomerasePRO_1000013953Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi441770.CLB_3335.

    Structurei

    3D structure databases

    ProteinModelPortaliA7FYM5.
    SMRiA7FYM5. Positions 4-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000100403.
    KOiK01810.
    OMAiGVESYKR.
    OrthoDBiEOG64R61J.

    Family and domain databases

    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7FYM5-1 [UniParc]FASTAAdd to Basket

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    MKNSLSLDLT KTKPYVEEHE LQYLESIIRE MDNTLGKKTG SGNKFLGWMD    50
    LPINYNKEEF ARIKKAAEKI KNTCDVFIVI GIGGSYLGSR AAIEMISNTF 100
    YNNLDKNQRK VPQIYFAGNN ISSTYMADLL ELVKDKDICV NVISKSGTTT 150
    EPAIAFRIFK ELLENKYGKE GAKERIFATT DAAKGALRTL ADSEGYETFV 200
    IPDDVGGRFS VLTPVGLLPI AASGIDIDEM MKGAADAREE YSSDNIEKNH 250
    VYRYVAVRNA LYRKGKTTEM LVNFEPCLHY FGEWWKQLYG ESEGKDGKGI 300
    FPAAADFSTD LHSMGQYIQE GLRNIFETFI NVENPRKSII VKEDKENLDG 350
    LNFLADKDMD YVNHQALRGT VLAHNDGGVP AMVLNVPELS AYYFGQLVYF 400
    FEKACGISGY LLGVNPFDQP GVEAYKKNMF ALLGKPGYEN MKATLEERLK 450
    Length:450
    Mass (Da):50,477
    Last modified:September 11, 2007 - v1
    Checksum:iA80E1468B9389680
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000726 Genomic DNA. Translation: ABS33866.1.
    RefSeqiYP_001385598.1. NC_009697.1.

    Genome annotation databases

    EnsemblBacteriaiABS33866; ABS33866; CLB_3335.
    GeneIDi5397977.
    KEGGicba:CLB_3335.
    PATRICi19361210. VBICloBot110701_3210.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000726 Genomic DNA. Translation: ABS33866.1 .
    RefSeqi YP_001385598.1. NC_009697.1.

    3D structure databases

    ProteinModelPortali A7FYM5.
    SMRi A7FYM5. Positions 4-449.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 441770.CLB_3335.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS33866 ; ABS33866 ; CLB_3335 .
    GeneIDi 5397977.
    KEGGi cba:CLB_3335.
    PATRICi 19361210. VBICloBot110701_3210.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000100403.
    KOi K01810.
    OMAi GVESYKR.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    UPA00138 .
    BioCyci CBOT441770:GH1E-3300-MONOMER.

    Family and domain databases

    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
      Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
      PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19397 / Type A.

    Entry informationi

    Entry nameiG6PI_CLOB1
    AccessioniPrimary (citable) accession number: A7FYM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3