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A7FX54

- GLSA_CLOB1

UniProt

A7FX54 - GLSA_CLOB1

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Protein

Glutaminase

Gene
glsA, CLB_2751
Organism
Clostridium botulinum (strain ATCC 19397 / Type A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611Substrate By similarity
Binding sitei113 – 1131Substrate By similarity
Binding sitei158 – 1581Substrate By similarity
Binding sitei165 – 1651Substrate By similarity
Binding sitei189 – 1891Substrate By similarity
Binding sitei241 – 2411Substrate By similarity
Binding sitei259 – 2591Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCBOT441770:GH1E-2720-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:CLB_2751
OrganismiClostridium botulinum (strain ATCC 19397 / Type A)
Taxonomic identifieri441770 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000006379: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305GlutaminaseUniRule annotationPRO_1000048330Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi441770.CLB_2751.

Structurei

3D structure databases

ProteinModelPortaliA7FX54.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiTHNDTLE.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

A7FX54-1 [UniParc]FASTAAdd to Basket

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MNRLLKTIIE NNRKWISEGK VASYIPELSK MDKNLLGISV CTLGGEEYWE    50
GDAEVKFTIQ SISKIVTLML AIIDNGEDYV FSKVGMEPTE TAFNSIVNLE 100
AKESHKPINP MINAGAIVVA SMVAGKDSDE KFDRILKFTR KISGNNDIDI 150
NLNVYESEKE TGHRNRALAY FMKSTGALKG NVEEILDVYF KQCSIEITCK 200
DLARIGVMLA NDGVSPYTGD RIVPRHVARI VKTIMVTCGM YDASGNFAVH 250
IGIPAKSGVG GGIIACAPRR MGIGVLGTAL DEKGNSIAGT KILEELSKQL 300
DLSIF 305
Length:305
Mass (Da):33,286
Last modified:September 11, 2007 - v1
Checksum:iB1C813A8CD343350
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000726 Genomic DNA. Translation: ABS32832.1.
RefSeqiYP_001385052.1. NC_009697.1.

Genome annotation databases

EnsemblBacteriaiABS32832; ABS32832; CLB_2751.
GeneIDi5396651.
KEGGicba:CLB_2751.
PATRICi19360058. VBICloBot110701_2664.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000726 Genomic DNA. Translation: ABS32832.1 .
RefSeqi YP_001385052.1. NC_009697.1.

3D structure databases

ProteinModelPortali A7FX54.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 441770.CLB_2751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS32832 ; ABS32832 ; CLB_2751 .
GeneIDi 5396651.
KEGGi cba:CLB_2751.
PATRICi 19360058. VBICloBot110701_2664.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi THNDTLE.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci CBOT441770:GH1E-2720-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
    Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
    PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19397 / Type A.

Entry informationi

Entry nameiGLSA_CLOB1
AccessioniPrimary (citable) accession number: A7FX54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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