Reviewed, UniProtKB/Swiss-Prot A7FW24 (ACKA_CLOB1)

Names and origin

Protein names

Recommended name:
    Acetate kinase
    EC=2.7.2.1
Alternative name(s):
    Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	CLB_2324

Organism

Clostridium botulinum (strain ATCC 19397 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

441770 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	Acetate kinase HAMAP MF_00020		PRO_1000002220

Sequences

	Sequence		Length	Mass (Da)
	A7FW24-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: AEA792DAF684F2DA	FASTA	397	43,430
	10 20 30 40 50 60 MKILVVNCGS SSLKYQLIDM TSEEALAKGL VERIGIEGSI LTQKVNGEKY IIEEPMKDHK 70 80 90 100 110 120 KAIELVLKAL VDKEHGVISD MSEIAAVGHR VVHGGEKYAS SVLINDEVMK ALEDCVKLAP 130 140 150 160 170 180 LHNPPNIIGI NACRELMPKT PMVAVFDTAF HQTLPDYAYM YPLPYELYEQ NGIRKYGFHG 190 200 210 220 230 240 TSHRYVSSVA SEMMGKDLKD LKVITCHLGN GASLCAVKEG KSVETSMGFT PLAGLAMGTR 250 260 270 280 290 300 CGDIDPAILL FMERELKMSP DEVDTVINKK SGVLGISGVS SDFRDIEGAA EEGNKRAKLA 310 320 330 340 350 360 LDVYHYTVRQ TIGAYTAVLN GVDAIVFTAG LGENSAASRE EILNGLEYLG IKIDAEKNKQ 370 380 390 RGKQIEISTE DSKVKVFVIP TDEELMIARD TKEITVK

References

[1]

"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids." Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S. PLoS ONE 2:E1271-E1271(2007) [PubMed: 18060065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000726 Genomic DNA. Translation: ABS32709.1.
RefSeq	YP_001384635.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5396212.
GenomeReviews	Gene locus CLB_2324 in contig CP000726_GR.
KEGG	cba:CLB_2324.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A7FW24. SSDFRDV.
Family and domain databases
HAMAP	MF_00020. [Tree]
InterPro	IPR000890. Acetate_kin. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_CLOB1

Accession

Primary (citable) accession number: A7FW24

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 11, 2007
Last modified:	June 16, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)