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A7FUX2

- A7FUX2_CLOB1

UniProt

A7FUX2 - A7FUX2_CLOB1

Protein

Glutamate decarboxylase

Gene

CLB_1854

Organism
Clostridium botulinum (strain ATCC 19397 / Type A)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciCBOT441770:GH1E-1831-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
    Gene namesi
    Ordered Locus Names:CLB_1854Imported
    OrganismiClostridium botulinum (strain ATCC 19397 / Type A)Imported
    Taxonomic identifieri441770 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000006379: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi441770.CLB_1854.

    Structurei

    3D structure databases

    ProteinModelPortaliA7FUX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0076.
    HOGENOMiHOG000070228.
    KOiK01580.
    OMAiKIHERTR.
    OrthoDBiEOG6TFCPW.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7FUX2-1 [UniParc]FASTAAdd to Basket

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    MLYSSKNKQS NDTYATPIFG ITKDKYSIPK YKINENSIAP NIAYRMIKDE    50
    LMNEGNARLN LATFCQTYME DKATKLMAET LQKNAIDKSE YPQTAEIENR 100
    CVNIISDLWN VPKDMNFLGT STVGSSEACM LGGMSMKFRW RDQAKKLGID 150
    INKKKPNLVI SSGYQVCWEK FCVYWDIEMR TVPMDEDNLS LNIDKILDYV 200
    DEYTIGIIGI LGITYTGKFD DIKALDDAIE KYNSNHDIKV YIHVDAASGG 250
    FFTPFINPEI LWDFRLKNVV SINASGHKYG LVYPGIGWIL WKDQEYLPKD 300
    LIFEVSYLGG KMPTLAINFS RSGSQIIGQY YNFLRFGFEG YKKIHERTKE 350
    VAMYISKELE ATGLFSIYND GSNLPIVCYK LKEQSKVKWN LYDLSDRLAM 400
    KGWQIPAYPL PENLNHIIIQ RIVCRSDLGY NLAELLIKDF KTAINDLNNA 450
    HILFHEEENQ GIYGFTH 467
    Length:467
    Mass (Da):53,660
    Last modified:September 11, 2007 - v1
    Checksum:i533231CB09C8E733
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000726 Genomic DNA. Translation: ABS33386.1.
    RefSeqiYP_001384175.1. NC_009697.1.

    Genome annotation databases

    EnsemblBacteriaiABS33386; ABS33386; CLB_1854.
    GeneIDi5394843.
    KEGGicba:CLB_1854.
    PATRICi19358294. VBICloBot110701_1782.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000726 Genomic DNA. Translation: ABS33386.1 .
    RefSeqi YP_001384175.1. NC_009697.1.

    3D structure databases

    ProteinModelPortali A7FUX2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 441770.CLB_1854.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS33386 ; ABS33386 ; CLB_1854 .
    GeneIDi 5394843.
    KEGGi cba:CLB_1854.
    PATRICi 19358294. VBICloBot110701_1782.

    Phylogenomic databases

    eggNOGi COG0076.
    HOGENOMi HOG000070228.
    KOi K01580.
    OMAi KIHERTR.
    OrthoDBi EOG6TFCPW.

    Enzyme and pathway databases

    BioCyci CBOT441770:GH1E-1831-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
      Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
      PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19397 / Type AImported.

    Entry informationi

    Entry nameiA7FUX2_CLOB1
    AccessioniPrimary (citable) accession number: A7FUX2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3