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A7FUT7 (A7FUT7_CLOB1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
EC=2.2.1.7 HAMAP MF_00315
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase HAMAP MF_00315
Gene names
Name:dxs HAMAP MF_00315 EMBL ABS33206.1
Ordered Locus Names:CLB_1818
OrganismClostridium botulinum (strain ATCC 19397 / Type A) [Complete proteome] [HAMAP]
Taxonomic identifier441770 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length622 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315 SAAS SAAS005477

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315 SAAS SAAS005477

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP MF_00315 SAAS SAAS005477

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315 SAAS SAAS005477

Subunit structure

Homodimer By similarity. HAMAP MF_00315 SAAS SAAS005477

Sequence similarities

Belongs to the transketolase family. DXPS subfamily. HAMAP MF_00315

Sequences

Sequence LengthMass (Da)Tools
A7FUT7 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: D70DE95D8F4864EA

FASTA62268,669
        10         20         30         40         50         60 
MKMKNILDKY QDFDSIKSMS INELNQFSYE IREFLIDNVS KTGGHLASNL GVVELTLSIF 

        70         80         90        100        110        120 
NVFDLNKDKV IWDVGHQAYV HKILTGRKDK FNTLRQYGGL SGFPKICESP YDVFETGHSS 

       130        140        150        160        170        180 
TSISAALGMA RARDIKGENN KVIAVIGDGA LTGGMALEAL NDLGFNKTDL IIILNDNQMS 

       190        200        210        220        230        240 
IAENVGGMSS YLSKVRLDPT YNKLKKEVNN TLNKIPNVGK GMARSLERVK NGIKQMIVPG 

       250        260        270        280        290        300 
MLFENLGIKY LGPIDGHDIK ELSKVMKMAK NINGPVLIHT ITKKGKGYAY AEKKPDKFHG 

       310        320        330        340        350        360 
IGPFDCDSGE VNSKTCLTYS KVFGEELTKI AKEDKKVVAI TAAMKDGTGL RKFGETFPKR 

       370        380        390        400        410        420 
FFDVGIAEQH AVTLAAGIAT EGLKPVFAVY STFLQRAYDQ ILHDICIQNL PVVLGIDRAG 

       430        440        450        460        470        480 
IVGSDGETHQ GIFDLSYLSS LPNMTIIAPK CLEEMGIMLR WALNQNSPVA IRYPRGGDIK 

       490        500        510        520        530        540 
SLEMTPIKNM KKGKWEVICE EGDIAIIATG KMVQHAIIAR EKLKEYGIKS TIVNANFIKP 

       550        560        570        580        590        600 
IDKELIKNFV KKGYKIVTVE DNVIKGGFGS LVLQYISELK ANNTVLNLGF KDKFVPHGST 

       610        620 
DILYKIEGLD PEGIVKNIIK II

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References

[1]"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
PLoS ONE 2:E1271-E1271(2007) [PubMed: 18060065] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000726 Genomic DNA. Translation: ABS33206.1.
RefSeqYP_001384140.1. NC_009697.1.

3D structure databases

ProteinModelPortalA7FUT7.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7FUT7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5396153.
GenomeReviewsGene locus CLB_1818 in contig CP000726_GR.
KEGGcba:CLB_1818.
PATRIC19358220. VBICloBot110701_1745.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1154.
HOGENOMHBG571647.
OMARAHEFES.
ProtClustDBPRK05444.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR005477. Dxylulose-5-P_synthase.
IPR011766. TPP_enzyme-bd_C.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7FUT7_CLOB1
AccessionPrimary (citable) accession number: A7FUT7
Entry history
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info