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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Clostridium botulinum (strain ATCC 19397 / Type A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCBOT441770:GH1E-960-MONOMER.
UniPathwayiUPA00148; UER00227.

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:CLB_0977
OrganismiClostridium botulinum (strain ATCC 19397 / Type A)
Taxonomic identifieri441770 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Cobalt-precorrin-5B C(1)-methyltransferasePRO_1000046853Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA7FSI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000009126.
KOiK02188.
OMAiMMVHSKS.

Family and domain databases

HAMAPiMF_00787. CbiD. 1 hit.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.

Sequencei

Sequence statusi: Complete.

A7FSI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDLYVNCDG KKLRCGYTTG SCAAAAAKAA AIALFYNKKL EEINIDTPKG
60 70 80 90 100
IELAIPIEKI VEDENFVECA VIKDGGDDVD ITHGIEIWAR AEKKSSGYTL
110 120 130 140 150
KGGKGVGVVC GEGLYVKKGE PAINPVPCSM IEKEVRSVMP KDSGVEITIF
160 170 180 190 200
VPKGEEIAKK TFNPRLNIIG GISILGTTGI VMPMSEDALK VSIELEINQK
210 220 230 240 250
TCHGEKELIL LFGNMGEKMA KELNLKEDNM VIMSNYVGFA LNCCMARKLE
260 270 280 290 300
KVTIVGHIGK ISKIASGCFN THSRVCDTRL ETLALELALM GYDKDLVTKI
310 320 330 340 350
YNEKTTEGAV NLLGEGYEKL YKNLGEKIIR KIEQYTYDSI KADIVMYSME

KGILYSSIE
Length:359
Mass (Da):39,365
Last modified:September 11, 2007 - v1
Checksum:iB88B3F8861A112FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000726 Genomic DNA. Translation: ABS35226.1.
RefSeqiWP_011948621.1. NC_009697.1.

Genome annotation databases

EnsemblBacteriaiABS35226; ABS35226; CLB_0977.
KEGGicba:CLB_0977.
PATRICi19356556. VBICloBot110701_0913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000726 Genomic DNA. Translation: ABS35226.1.
RefSeqiWP_011948621.1. NC_009697.1.

3D structure databases

ProteinModelPortaliA7FSI4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS35226; ABS35226; CLB_0977.
KEGGicba:CLB_0977.
PATRICi19356556. VBICloBot110701_0913.

Phylogenomic databases

HOGENOMiHOG000009126.
KOiK02188.
OMAiMMVHSKS.

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227.
BioCyciCBOT441770:GH1E-960-MONOMER.

Family and domain databases

HAMAPiMF_00787. CbiD. 1 hit.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCBID_CLOB1
AccessioniPrimary (citable) accession number: A7FSI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: September 7, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.