A7FRG6 (A7FRG6_CLOB1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Large-conductance mechanosensitive channel HAMAP MF_00115

Gene names

Name:	mscL HAMAP MF_00115 EMBL ABS33244.1
Ordered Locus Names:	CLB_0594

Organism

Clostridium botulinum (strain ATCC 19397 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

441770 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	133 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP MF_00115
Subunit structure	Homopentamer By similarity. HAMAP MF_00115
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00115.
Sequence similarities	Belongs to the MscL family. HAMAP MF_00115

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane HAMAP MF_00115 SAAS SAAS001185 Membrane
Domain	Transmembrane Transmembrane helix HAMAP MF_00115 SAAS SAAS001185
Molecular function	Ionic channel HAMAP MF_00115 SAAS SAAS001185
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Transmembrane	33 – 53	21	Helical; By similarity HAMAP MF_00115
	Transmembrane	78 – 98	21	Helical; By similarity HAMAP MF_00115

Sequences

	Sequence		Length	Mass (Da)
	A7FRG6 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 2386092CAC59E91C	FASTA	133	14,841
	10 20 30 40 50 60 MKKIIEEFKD FAVKGNAIEL AVGVVIGSAF GKIVTSLVED IIMPLVGLLI GGIDFTGLKF 70 80 90 100 110 120 SMNLSGKTVV SINYGNFIQA AVNFLIISFS IFLFIKLINK FKQNEEEEKD EPKISNEEIL 130 LREIRDLLKE NKS

References

[1]

"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids." Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S. PLoS ONE 2:E1271-E1271(2007) [PubMed: 18060065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000726 Genomic DNA. Translation: ABS33244.1.
RefSeq	YP_001382943.1. NC_009697.1.
3D structure databases
ProteinModelPortal	A7FRG6.
ModBase	Search...
Protein-protein interaction databases
STRING	A7FRG6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5398085.
GenomeReviews	Gene locus CLB_0594 in contig CP000726_GR.
KEGG	cba:CLB_0594.
PATRIC	19355808. VBICloBot110701_0539.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1970.
HOGENOM	HBG727604.
OMA	VIDFVIV.
ProtClustDB	CLSK971647.
Family and domain databases
HAMAP	MF_00115. MscL. [Tree]
InterPro	IPR001185. MS_channel. [Graphical view]
KO	K03282.
Pfam	PF01741. MscL. 1 hit. [Graphical view]
PRINTS	PR01264. MECHCHANNEL.
SUPFAM	SSF81330. MS_channel. 1 hit.
TIGRFAMs	TIGR00220. MscL. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A7FRG6_CLOB1

Accession

Primary (citable) accession number: A7FRG6

Entry history

Integrated into UniProtKB/TrEMBL:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)