A7FPH4 (COMB_CLOB1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 2-phosphosulfolactate phosphatase
EC=3.1.3.71

Gene names

Name:	comB
Ordered Locus Names:	CLB_3635

Organism

Clostridium botulinum (strain ATCC 19397 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

441770 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate. HAMAP MF_00490
Cofactor	Magnesium By similarity. HAMAP MF_00490
Sequence similarities	Belongs to the ComB family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme M biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	2-phosphosulfolactate phosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 239	239	Probable 2-phosphosulfolactate phosphatase HAMAP MF_00490		PRO_1000014460

Sequences

	Sequence		Length	Mass (Da)
	A7FPH4 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 0BF3B8F51CF732B0	FASTA	239	26,658
	10 20 30 40 50 60 MNIDIVISAD HIDEKGLINK TVIIIDILRA TSVITTAINN GCKKVIPVLT VEEAKDIAKN 70 80 90 100 110 120 SEEDIILGGE RNALKIDGFN FSNSPLEYTK KYVEGKTVVL STTNGTRAIN NSFNAKTILI 130 140 150 160 170 180 SALINSKATA KAIDKLHEDL IIINSGTNGQ FSIDDFICSG YLIDCLYNIR KDLELSDIAK 190 200 210 220 230 TAHYIYTNNK DIESFVKKAT HYSRLKSLNL EKDLEYCFQK DIIDVVPQYK DGYIIKSNI

References

[1]

"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids." Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S. PLoS ONE 2:E1271-E1271(2007) [PubMed: 18060065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19397 / Type A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000726 Genomic DNA. Translation: ABS35102.1.
RefSeq	YP_001385868.1. NC_009697.1.
3D structure databases
ProteinModelPortal	A7FPH4.
SMR	A7FPH4. Positions 1-235.
ModBase	Search...
Protein-protein interaction databases
STRING	A7FPH4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5396292.
GenomeReviews	Gene locus CLB_3635 in contig CP000726_GR.
KEGG	cba:CLB_3635.
PATRIC	19361808. VBICloBot110701_3486.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2045.
HOGENOM	HBG633644.
OMA	DFICSGY.
ProtClustDB	PRK00886.
Enzyme and pathway databases
BioCyc	CBOT441770:CLB_3635-MONOMER.
Family and domain databases
HAMAP	MF_00490. ComB. [Tree]
InterPro	IPR005238. 2-PSlactate_phosphatase. IPR022995. Pase_ComB. [Graphical view]
Gene3D	G3DSA:3.90.1560.10. 2-PSlactate_phosphatase. 1 hit.
KO	K05979.
Pfam	PF04029. 2-ph_phosp. 1 hit. [Graphical view]
SUPFAM	SSF142823. SSF142823. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COMB_CLOB1

Accession

Primary (citable) accession number: A7FPH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 11, 2007
Last modified:	December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program