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Protein

Probable 2-phosphosulfolactate phosphatase

Gene

comB

Organism
Clostridium botulinum (strain ATCC 19397 / Type A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciCBOT441770:GH1E-3596-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-phosphosulfolactate phosphataseUniRule annotation (EC:3.1.3.71UniRule annotation)
Gene namesi
Name:comBUniRule annotation
Ordered Locus Names:CLB_3635
OrganismiClostridium botulinum (strain ATCC 19397 / Type A)
Taxonomic identifieri441770 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Probable 2-phosphosulfolactate phosphatasePRO_1000014460Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA7FPH4.
SMRiA7FPH4. Positions 1-235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ComB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000232676.
KOiK05979.
OMAiFRATSCM.
OrthoDBiEOG6SNDT4.

Family and domain databases

Gene3Di3.90.1560.10. 1 hit.
HAMAPiMF_00490. ComB.
InterProiIPR005238. ComB-like.
IPR022995. ProB_Pase_ComB.
[Graphical view]
PfamiPF04029. 2-ph_phosp. 1 hit.
[Graphical view]
SUPFAMiSSF142823. SSF142823. 1 hit.

Sequencei

Sequence statusi: Complete.

A7FPH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIDIVISAD HIDEKGLINK TVIIIDILRA TSVITTAINN GCKKVIPVLT
60 70 80 90 100
VEEAKDIAKN SEEDIILGGE RNALKIDGFN FSNSPLEYTK KYVEGKTVVL
110 120 130 140 150
STTNGTRAIN NSFNAKTILI SALINSKATA KAIDKLHEDL IIINSGTNGQ
160 170 180 190 200
FSIDDFICSG YLIDCLYNIR KDLELSDIAK TAHYIYTNNK DIESFVKKAT
210 220 230
HYSRLKSLNL EKDLEYCFQK DIIDVVPQYK DGYIIKSNI
Length:239
Mass (Da):26,658
Last modified:September 11, 2007 - v1
Checksum:i0BF3B8F51CF732B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000726 Genomic DNA. Translation: ABS35102.1.
RefSeqiWP_012099545.1. NC_009697.1.

Genome annotation databases

EnsemblBacteriaiABS35102; ABS35102; CLB_3635.
KEGGicba:CLB_3635.
PATRICi19361808. VBICloBot110701_3486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000726 Genomic DNA. Translation: ABS35102.1.
RefSeqiWP_012099545.1. NC_009697.1.

3D structure databases

ProteinModelPortaliA7FPH4.
SMRiA7FPH4. Positions 1-235.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS35102; ABS35102; CLB_3635.
KEGGicba:CLB_3635.
PATRICi19361808. VBICloBot110701_3486.

Phylogenomic databases

HOGENOMiHOG000232676.
KOiK05979.
OMAiFRATSCM.
OrthoDBiEOG6SNDT4.

Enzyme and pathway databases

BioCyciCBOT441770:GH1E-3596-MONOMER.

Family and domain databases

Gene3Di3.90.1560.10. 1 hit.
HAMAPiMF_00490. ComB.
InterProiIPR005238. ComB-like.
IPR022995. ProB_Pase_ComB.
[Graphical view]
PfamiPF04029. 2-ph_phosp. 1 hit.
[Graphical view]
SUPFAMiSSF142823. SSF142823. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
    Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
    PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19397 / Type A.

Entry informationi

Entry nameiCOMB_CLOB1
AccessioniPrimary (citable) accession number: A7FPH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: December 9, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.