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Protein

Endonuclease V

Gene

nfi

Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361MagnesiumUniRule annotation
Metal bindingi104 – 1041MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciYPSE349747:GH71-3947-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease VUniRule annotation (EC:3.1.21.7UniRule annotation)
Alternative name(s):
Deoxyinosine 3'endonucleaseUniRule annotation
Deoxyribonuclease VUniRule annotation
Short name:
DNase VUniRule annotation
Gene namesi
Name:nfiUniRule annotation
Ordered Locus Names:YpsIP31758_3848
OrganismiYersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Taxonomic identifieri349747 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000002412 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Endonuclease VPRO_1000062264Add
BLAST

Interactioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei74 – 741Interaction with target DNAUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA7FNH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endonuclease V family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229135.
KOiK05982.
OMAiREYPALM.

Family and domain databases

CDDicd06559. Endonuclease_V. 1 hit.
HAMAPiMF_00801. Endonuclease_5. 1 hit.
InterProiIPR007581. Endonuclease-V.
[Graphical view]
PfamiPF04493. Endonuclease_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7FNH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDTKALQAE QRQRASEISL HDGIDNQFVR FIAGADVGFE QHGEITRAAI
60 70 80 90 100
AILRYPSLAL VEYQVARVAT SLPYIPGLLS FREYPALLAA WAQLQQRPDL
110 120 130 140 150
ILVDGQGIAH PRRLGVASHF GLLVDVPTIG VAKSRLCGDF LPLHQDVGAV
160 170 180 190 200
QPLFDNDEQL GWVWRSKIRC NPLFISPGHR VSVGSALAWV QRCMAGYRLP
210 220 230
EPTRWADAIA SNRPQFQRWL RKNPDFLGKR RDMI
Length:234
Mass (Da):26,304
Last modified:September 11, 2007 - v1
Checksum:iCDDCD012D3ED5905
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000720 Genomic DNA. Translation: ABS49813.1.
RefSeqiWP_011191556.1. NC_009708.1.

Genome annotation databases

EnsemblBacteriaiABS49813; ABS49813; YpsIP31758_3848.
KEGGiypi:YpsIP31758_3848.
PATRICi18636977. VBIYerPse15693_4386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000720 Genomic DNA. Translation: ABS49813.1.
RefSeqiWP_011191556.1. NC_009708.1.

3D structure databases

ProteinModelPortaliA7FNH1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS49813; ABS49813; YpsIP31758_3848.
KEGGiypi:YpsIP31758_3848.
PATRICi18636977. VBIYerPse15693_4386.

Phylogenomic databases

HOGENOMiHOG000229135.
KOiK05982.
OMAiREYPALM.

Enzyme and pathway databases

BioCyciYPSE349747:GH71-3947-MONOMER.

Family and domain databases

CDDicd06559. Endonuclease_V. 1 hit.
HAMAPiMF_00801. Endonuclease_5. 1 hit.
InterProiIPR007581. Endonuclease-V.
[Graphical view]
PfamiPF04493. Endonuclease_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNFI_YERP3
AccessioniPrimary (citable) accession number: A7FNH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: September 7, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.