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A7FLX5

- SURE_YERP3

UniProt

A7FLX5 - SURE_YERP3

Protein

5'/3'-nucleotidase SurE

Gene

surE

Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.UniRule annotation

    Catalytic activityi

    A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
    A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
    (Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.UniRule annotation

    Cofactori

    Binds 1 divalent metal cation per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi9 – 91Divalent metal cationUniRule annotation
    Metal bindingi10 – 101Divalent metal cationUniRule annotation
    Metal bindingi40 – 401Divalent metal cationUniRule annotation
    Metal bindingi93 – 931Divalent metal cationUniRule annotation

    GO - Molecular functioni

    1. 3'-nucleotidase activity Source: UniProtKB-HAMAP
    2. 5'-nucleotidase activity Source: UniProtKB-HAMAP
    3. exopolyphosphatase activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-HAMAP
    5. nucleotide binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYPSE349747:GH71-3384-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5'/3'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation, EC:3.1.3.6UniRule annotation)
    Alternative name(s):
    ExopolyphosphataseUniRule annotation (EC:3.6.1.11UniRule annotation)
    Nucleoside monophosphate phosphohydrolaseUniRule annotation
    Gene namesi
    Name:surEUniRule annotation
    Ordered Locus Names:YpsIP31758_3296
    OrganismiYersinia pseudotuberculosis serotype O:1b (strain IP 31758)
    Taxonomic identifieri349747 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000002412: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2542545'/3'-nucleotidase SurEPRO_1000057415Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349747.YpsIP31758_3296.

    Structurei

    3D structure databases

    ProteinModelPortaliA7FLX5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SurE nucleotidase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0496.
    HOGENOMiHOG000122500.
    KOiK03787.
    OMAiVCDLIPK.
    OrthoDBiEOG68WR45.

    Family and domain databases

    Gene3Di3.40.1210.10. 1 hit.
    HAMAPiMF_00060. SurE.
    InterProiIPR002828. SurE-like_Pase/nucleotidase.
    [Graphical view]
    PfamiPF01975. SurE. 1 hit.
    [Graphical view]
    SUPFAMiSSF64167. SSF64167. 1 hit.
    TIGRFAMsiTIGR00087. surE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7FLX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIRILLSNDD GISAPGIQTL ASALREFAQV QIVAPDRNRS GASNALTLDS    50
    ALRITTLSNG DIAVQQGTPT DCVYLGVNAL MRPRPDIVVS GINAGPNLGD 100
    DVIYSGTVAA AMEGRHLGYP ALAVSLNGHQ HYDTAAAVTC RLLRALQRKP 150
    LRTGKILNIN VPDLPLSEIK GIRVTRCGSR HPAEQVFCQQ DPRGQDLYWI 200
    GPPGEKYDAG PDTDFAAVEQ GYVSITPLQV DLTAYTAQEV VESWLANTEV 250
    DGEW 254
    Length:254
    Mass (Da):27,289
    Last modified:September 11, 2007 - v1
    Checksum:iC1BBACEC6F9B2661
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000720 Genomic DNA. Translation: ABS47039.1.
    RefSeqiYP_001402253.1. NC_009708.1.

    Genome annotation databases

    EnsemblBacteriaiABS47039; ABS47039; YpsIP31758_3296.
    GeneIDi5386871.
    KEGGiypi:YpsIP31758_3296.
    PATRICi18635753. VBIYerPse15693_3785.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000720 Genomic DNA. Translation: ABS47039.1 .
    RefSeqi YP_001402253.1. NC_009708.1.

    3D structure databases

    ProteinModelPortali A7FLX5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349747.YpsIP31758_3296.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS47039 ; ABS47039 ; YpsIP31758_3296 .
    GeneIDi 5386871.
    KEGGi ypi:YpsIP31758_3296.
    PATRICi 18635753. VBIYerPse15693_3785.

    Phylogenomic databases

    eggNOGi COG0496.
    HOGENOMi HOG000122500.
    KOi K03787.
    OMAi VCDLIPK.
    OrthoDBi EOG68WR45.

    Enzyme and pathway databases

    BioCyci YPSE349747:GH71-3384-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1210.10. 1 hit.
    HAMAPi MF_00060. SurE.
    InterProi IPR002828. SurE-like_Pase/nucleotidase.
    [Graphical view ]
    Pfami PF01975. SurE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64167. SSF64167. 1 hit.
    TIGRFAMsi TIGR00087. surE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever."
      Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G., Fayolle C., Lindler L.E., Carniel E., Ravel J.
      PLoS Genet. 3:1508-1523(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IP 31758.

    Entry informationi

    Entry nameiSURE_YERP3
    AccessioniPrimary (citable) accession number: A7FLX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3