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A7FLK2

- GMHA_YERP3

UniProt

A7FLK2 - GMHA_YERP3

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Protein

Phosphoheptose isomerase

Gene

gmhA

Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Catalytic activityi

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611ZincUniRule annotation
Metal bindingi65 – 651ZincUniRule annotation
Binding sitei65 – 651SubstrateUniRule annotation
Binding sitei124 – 1241SubstrateUniRule annotation
Metal bindingi172 – 1721ZincUniRule annotation
Binding sitei172 – 1721SubstrateUniRule annotation
Metal bindingi180 – 1801ZincUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. D-sedoheptulose 7-phosphate isomerase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-glycero-D-manno-heptose 7-phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. lipopolysaccharide core region biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYPSE349747:GH71-3250-MONOMER.
UniPathwayiUPA00041; UER00436.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoheptose isomeraseUniRule annotation (EC:5.3.1.28UniRule annotation)
Alternative name(s):
Sedoheptulose 7-phosphate isomeraseUniRule annotation
Gene namesi
Name:gmhAUniRule annotation
Ordered Locus Names:YpsIP31758_3170
OrganismiYersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Taxonomic identifieri349747 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000002412: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Phosphoheptose isomerasePRO_1000057454Add
BLAST

Proteomic databases

PRIDEiA7FLK2.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi349747.YpsIP31758_3170.

Structurei

3D structure databases

ProteinModelPortaliA7FLK2.
SMRiA7FLK2. Positions 1-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 193157SISUniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 543Substrate bindingUniRule annotation
Regioni93 – 942Substrate bindingUniRule annotation
Regioni119 – 1213Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the SIS family. GmhA subfamily.UniRule annotation
Contains 1 SIS domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0279.
HOGENOMiHOG000237571.
KOiK03271.
OMAiHVFSRYV.
OrthoDBiEOG6384PC.

Family and domain databases

HAMAPiMF_00067. GmhA.
InterProiIPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view]
PfamiPF13580. SIS_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00441. gmhA. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7FLK2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYHDLIRSEL NEAADTLANF LKDDSNIDAI QRAAILLADS FKAGGKVLSC
60 70 80 90 100
GNGGSHCDAM HFAEELTGRY RENRPGYPAI AISDVSHLSC VSNDFGYDYV
110 120 130 140 150
FSRYVEAVGR EGDVLLGIST SGNSGNIIKA IEAARAKGMK VITLTGKDGG
160 170 180 190
KMAGSADIEI RVPHFGYADR IQEIHIKVIH ILIQLIEKEM VKA
Length:193
Mass (Da):20,929
Last modified:September 11, 2007 - v1
Checksum:i373DCD0C362AD0EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000720 Genomic DNA. Translation: ABS49655.1.
RefSeqiYP_001402130.1. NC_009708.1.

Genome annotation databases

EnsemblBacteriaiABS49655; ABS49655; YpsIP31758_3170.
GeneIDi5385868.
KEGGiypi:YpsIP31758_3170.
PATRICi18635467. VBIYerPse15693_3652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000720 Genomic DNA. Translation: ABS49655.1 .
RefSeqi YP_001402130.1. NC_009708.1.

3D structure databases

ProteinModelPortali A7FLK2.
SMRi A7FLK2. Positions 1-192.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349747.YpsIP31758_3170.

Proteomic databases

PRIDEi A7FLK2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS49655 ; ABS49655 ; YpsIP31758_3170 .
GeneIDi 5385868.
KEGGi ypi:YpsIP31758_3170.
PATRICi 18635467. VBIYerPse15693_3652.

Phylogenomic databases

eggNOGi COG0279.
HOGENOMi HOG000237571.
KOi K03271.
OMAi HVFSRYV.
OrthoDBi EOG6384PC.

Enzyme and pathway databases

UniPathwayi UPA00041 ; UER00436 .
BioCyci YPSE349747:GH71-3250-MONOMER.

Family and domain databases

HAMAPi MF_00067. GmhA.
InterProi IPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view ]
Pfami PF13580. SIS_2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00441. gmhA. 1 hit.
PROSITEi PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever."
    Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G., Fayolle C., Lindler L.E., Carniel E., Ravel J.
    PLoS Genet. 3:1508-1523(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP 31758.

Entry informationi

Entry nameiGMHA_YERP3
AccessioniPrimary (citable) accession number: A7FLK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.UniRule annotation

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3