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A7FLK2

- GMHA_YERP3

UniProt

A7FLK2 - GMHA_YERP3

Protein

Phosphoheptose isomerase

Gene

gmhA

Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

    Catalytic activityi

    D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi61 – 611ZincUniRule annotation
    Metal bindingi65 – 651ZincUniRule annotation
    Binding sitei65 – 651SubstrateUniRule annotation
    Binding sitei124 – 1241SubstrateUniRule annotation
    Metal bindingi172 – 1721ZincUniRule annotation
    Binding sitei172 – 1721SubstrateUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. D-sedoheptulose 7-phosphate isomerase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-glycero-D-manno-heptose 7-phosphate biosynthetic process Source: UniProtKB-UniPathway
    2. lipopolysaccharide core region biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYPSE349747:GH71-3250-MONOMER.
    UniPathwayiUPA00041; UER00436.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoheptose isomeraseUniRule annotation (EC:5.3.1.28UniRule annotation)
    Alternative name(s):
    Sedoheptulose 7-phosphate isomeraseUniRule annotation
    Gene namesi
    Name:gmhAUniRule annotation
    Ordered Locus Names:YpsIP31758_3170
    OrganismiYersinia pseudotuberculosis serotype O:1b (strain IP 31758)
    Taxonomic identifieri349747 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000002412: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 193193Phosphoheptose isomerasePRO_1000057454Add
    BLAST

    Proteomic databases

    PRIDEiA7FLK2.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi349747.YpsIP31758_3170.

    Structurei

    3D structure databases

    ProteinModelPortaliA7FLK2.
    SMRiA7FLK2. Positions 1-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 193157SISUniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni52 – 543Substrate bindingUniRule annotation
    Regioni93 – 942Substrate bindingUniRule annotation
    Regioni119 – 1213Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the SIS family. GmhA subfamily.UniRule annotation
    Contains 1 SIS domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0279.
    HOGENOMiHOG000237571.
    KOiK03271.
    OMAiHVFSRYV.
    OrthoDBiEOG6384PC.

    Family and domain databases

    HAMAPiMF_00067. GmhA.
    InterProiIPR004515. Phosphoheptose_Isoase.
    IPR001347. SIS.
    [Graphical view]
    PfamiPF13580. SIS_2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00441. gmhA. 1 hit.
    PROSITEiPS51464. SIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7FLK2-1 [UniParc]FASTAAdd to Basket

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    MYHDLIRSEL NEAADTLANF LKDDSNIDAI QRAAILLADS FKAGGKVLSC    50
    GNGGSHCDAM HFAEELTGRY RENRPGYPAI AISDVSHLSC VSNDFGYDYV 100
    FSRYVEAVGR EGDVLLGIST SGNSGNIIKA IEAARAKGMK VITLTGKDGG 150
    KMAGSADIEI RVPHFGYADR IQEIHIKVIH ILIQLIEKEM VKA 193
    Length:193
    Mass (Da):20,929
    Last modified:September 11, 2007 - v1
    Checksum:i373DCD0C362AD0EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000720 Genomic DNA. Translation: ABS49655.1.
    RefSeqiYP_001402130.1. NC_009708.1.

    Genome annotation databases

    EnsemblBacteriaiABS49655; ABS49655; YpsIP31758_3170.
    GeneIDi5385868.
    KEGGiypi:YpsIP31758_3170.
    PATRICi18635467. VBIYerPse15693_3652.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000720 Genomic DNA. Translation: ABS49655.1 .
    RefSeqi YP_001402130.1. NC_009708.1.

    3D structure databases

    ProteinModelPortali A7FLK2.
    SMRi A7FLK2. Positions 1-192.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349747.YpsIP31758_3170.

    Proteomic databases

    PRIDEi A7FLK2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS49655 ; ABS49655 ; YpsIP31758_3170 .
    GeneIDi 5385868.
    KEGGi ypi:YpsIP31758_3170.
    PATRICi 18635467. VBIYerPse15693_3652.

    Phylogenomic databases

    eggNOGi COG0279.
    HOGENOMi HOG000237571.
    KOi K03271.
    OMAi HVFSRYV.
    OrthoDBi EOG6384PC.

    Enzyme and pathway databases

    UniPathwayi UPA00041 ; UER00436 .
    BioCyci YPSE349747:GH71-3250-MONOMER.

    Family and domain databases

    HAMAPi MF_00067. GmhA.
    InterProi IPR004515. Phosphoheptose_Isoase.
    IPR001347. SIS.
    [Graphical view ]
    Pfami PF13580. SIS_2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00441. gmhA. 1 hit.
    PROSITEi PS51464. SIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever."
      Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G., Fayolle C., Lindler L.E., Carniel E., Ravel J.
      PLoS Genet. 3:1508-1523(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IP 31758.

    Entry informationi

    Entry nameiGMHA_YERP3
    AccessioniPrimary (citable) accession number: A7FLK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3