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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei622ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:YpsIP31758_2926
OrganismiYersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Taxonomic identifieri349747 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000002412 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000573491 – 860Leucine--tRNA ligaseAdd BLAST860

Proteomic databases

PRIDEiA7FKW0

Structurei

3D structure databases

ProteinModelPortaliA7FKW0
SMRiA7FKW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi619 – 623"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A7FKW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEQYRPEDI ETQVQLHWQE KQTFKVTEDA SKEKYYCLSM LPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VISRYQRMLG KNVLQPIGWD AFGLPAEGAA VKNNTAPAPW
110 120 130 140 150
TYDNIEYMKN QLKLLGFGYD WDREIATCKP DYYRWEQWFF TKLYEKGMVY
160 170 180 190 200
KKTSAVNWCP HDLTVLANEQ VIDGCCWRCD TKVERKEIPQ WFIKITDYAE
210 220 230 240 250
QLLNDLDTLE SWPEQVKTMQ RNWIGRSEGV DIVFDVVDSE EKLSVYTTRP
260 270 280 290 300
DTFMGVTYVA VAAGHPLSLQ AAATNPALAD FVAECRNTKV AEAEMATMEK
310 320 330 340 350
KGMATGLYAI HPLTGEKLPI WAANFVLMDY GTGAVMAVPG HDARDWEFAT
360 370 380 390 400
KYNLPIKPVI LAADGSEPDL SQEAMTEKGT LFNSGEFDGL NHEDGFNAIA
410 420 430 440 450
DKLVALGVGQ RKVNYRLRDW GVSRQRYWGA PIPMVTLEDG TVVPTPEDQL
460 470 480 490 500
PVILPEDVVM DGISSPIKAD PEWAKTTVNG IPGLRETDTF DTFMESSWYY
510 520 530 540 550
ARYTCPQYDD GMLDPAAANY WLPVDQYVGG IEHAIMHLMY FRFFHKLLRD
560 570 580 590 600
AGLVDSDEPA KRLLCQGMVL ADAFYYTGNN GERIWVSPVD AIVERDDKGR
610 620 630 640 650
IVKAVDAEGH ELVYAGMSKM SKSKNNGIDP QVMVEKYGAD TVRLFMMFAS
660 670 680 690 700
PAEMTLEWQE SGVEGANRFL KRVWRLAFDH TAKGAVKPLD IASLTEEQKS
710 720 730 740 750
LRRDLHKTIA KVTDDVGRRQ TFNTAIAAVM ELMNKLGRAP QETEQDRALM
760 770 780 790 800
QEALLAVVRM LYPFTPHVCF SLWQALGGEG DIDTAPWPIA DEQAMVEDSK
810 820 830 840 850
LVVVQVNGKV RGRITVPADA TEQQVRERAG QEHLVAKYLD GVTVRKVIYV
860
PGKLLNLVVG
Length:860
Mass (Da):97,051
Last modified:September 11, 2007 - v1
Checksum:i34DA41D2A01FD153
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000720 Genomic DNA Translation: ABS47710.1
RefSeqiWP_002210333.1, NC_009708.1

Genome annotation databases

EnsemblBacteriaiABS47710; ABS47710; YpsIP31758_2926
KEGGiypi:YpsIP31758_2926

Similar proteinsi

Entry informationi

Entry nameiSYL_YERP3
AccessioniPrimary (citable) accession number: A7FKW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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