A7FKL6 (BETA_YERP3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Choline dehydrogenase
Short name=CDH
Short name=CHD
EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	YpsIP31758_2831

Organism

Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) [Complete proteome] [HAMAP]

Taxonomic identifier

349747 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	567 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750
Cofactor	FAD By similarity. HAMAP MF_00750
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: InterPro
Molecular function	choline dehydrogenase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 567	567	Choline dehydrogenase HAMAP MF_00750		PRO_1000062189
Regions
	Nucleotide binding	4 – 33	30	FAD Potential
Sites
	Active site	473	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7FKL6 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 92BE1D8C27D1FABD	FASTA	567	62,529
	10 20 30 40 50 60 MEYDYIIIGA GSAGNVLAAR LTEDADVTVL LLEAGGPDYR LDFRTQMPAA LAFPLQGKRY 70 80 90 100 110 120 NWAYETDPEP HMNNRRMECG RGKGLGGSSL INGMCYIRGN AMDFDHWASL SGLEDWSYLD 130 140 150 160 170 180 CLPYFRKAET RDIGPNDFHG GEGPVNVTTP KIGNNPLFHA MVAAGVQAGY PRTDDLNGYQ 190 200 210 220 230 240 QEGFGPMDRT VTPKGRRAST ARGYLDQARP RNNLTIITHA LTDRILFEGK RATGVRYLKG 250 260 270 280 290 300 DAGTGQTAYA RREVLLCGGA IASPQILQRS GIGPAELLQR LDIPLVQALP GVGENLQDHL 310 320 330 340 350 360 EMYLQYSCKQ PVSLYPALLW FNQPKIGIEW LFNGTGVGAS NQFEAGGFIR SRDAFTWPNI 370 380 390 400 410 420 QYHFLPVAIN YNGSNAVKEH GFQAHVGSMR SPSRGRIQVK SKDPRQHPSI LFNYMSSEQD 430 440 450 460 470 480 WHEFRDAIRI TREIIAQPAL DPYRGREISP GANVQNDDEL DAFIREHAET AYHPSCSCKM 490 500 510 520 530 540 GDDKMAVVDG QGRVHGVQGL RVVDASIMPQ IITGNLNATT IMIAEKIADR IRGCQPLAKS 550 560 NAAYFIAGDT PARTSPVRHS LPVTSYP

References

[1]

"The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever." Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G., Fayolle C., Lindler L.E., Carniel E., Ravel J. PLoS Genet. 3:1508-1523(2007) [PubMed: 17784789] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IP 31758.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000720 Genomic DNA. Translation: ABS49607.1.
RefSeq	YP_001401794.1. NC_009708.1.
3D structure databases
ProteinModelPortal	A7FKL6.
ModBase	Search...
Protein-protein interaction databases
STRING	A7FKL6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5387676.
GenomeReviews	Gene locus YpsIP31758_2831 in contig CP000720_GR.
KEGG	ypi:YpsIP31758_2831.
NMPDR	fig|349747.3.peg.3873.
PATRIC	18634701. VBIYerPse15693_3284.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2303.
HOGENOM	HBG734713.
OMA	RSTAPYY.
ProtClustDB	PRK02106.
Enzyme and pathway databases
BioCyc	YPSE349747:YPSIP31758_2831-MONOMER.
Family and domain databases
HAMAP	MF_00750. Choline_dehydrogen. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
KO	K00108.
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. BetA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_YERP3

Accession

Primary (citable) accession number: A7FKL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 11, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program