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A7FKF3 (A7FKF3_YERP3) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length897 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1221O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
A7FKF3 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: F0E7EADB759AAC69

FASTA89799,303
        10         20         30         40         50         60 
MSDLAREITP VNIEEELKSS YLDYAMSVIV GRALPDVRDG LKPVHRRVLF AMNVLGNDWN 

        70         80         90        100        110        120 
KPYKKSARVV GDVIGKYHPH GDSAVYDTIV RMAQPFSLRY MLVDGQGNFG SVDGDSAAAM 

       130        140        150        160        170        180 
RYTEIRMSKI AHELLADLEK DTVDFVPNYD GTEQIPAVMP TRIPNLLVNG SSGIAVGMAT 

       190        200        210        220        230        240 
NIPPHNLSEV IDGCLAYIED ENISIEGLME YIPGPDFPTA AIINGRRGIE EAYRTGRGKV 

       250        260        270        280        290        300 
YIRARAEVEA DAKTGRETII VHEIPYQVNK ARLIEKIAEL VKEKRVEGIS ALRDESDKDG 

       310        320        330        340        350        360 
MRIVIEIKRD AVGEVVLNNL YSLTQLQVTF GINMVALSQG QPKLLNLKDI LVAFVRHRRE 

       370        380        390        400        410        420 
VVTRRTIFEL RKARDRAHIL EALAIALANI DPIIELIRRA STPAEAKAGL IASPWELGNV 

       430        440        450        460        470        480 
ASMLERAGDD AARPEWLEAE FGIRDGKYYL TEQQAQAILD LRLQKLTGLE HEKLLDEYKE 

       490        500        510        520        530        540 
LLTLIGELIF ILENPDRLME VIREELVAIK EQYNDLRRTE ITANTSDINI EDLINQEDVV 

       550        560        570        580        590        600 
VTLSHQGYVK YQPLSDYEAQ RRGGKGKSAA RIKEEDFIDR LLVANTHDTI LCFSSRGRLY 

       610        620        630        640        650        660 
WMKVYQLPEA SRGARGRPIV NLLPLEPNER ITAILPVREY EEGRHVFMAT ASGTVKKTAL 

       670        680        690        700        710        720 
TEFSRPRSAG IIAVNLNEGD ELIGVDLTDG SNEVMLFSAL GKVVRFPEGQ VRSMGRTATG 

       730        740        750        760        770        780 
VRGINLNGDD RVISLIIPRG DGEILTVTEN GYGKRTAVAE YPTKSRATQG VISIKVSERN 

       790        800        810        820        830        840 
GKVVGAVQVA PTDQIMMITD AGTLVRTRVS EVSVVGRNTQ GVTLIRTAED EHVVGLQRVA 

       850        860        870        880        890 
EPEEDDDILD GESSEGEEGS EENAALNAPS DDVADEDTDA EDDTDAEDDT DVEDDNA

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References

[1]"The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever."
Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G., Fayolle C., Lindler L.E., Carniel E., Ravel J.
PLoS Genet. 3:E142-E142(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IP 31758 EMBL ABS48911.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000720 Genomic DNA. Translation: ABS48911.1.
RefSeqYP_001401731.1. NC_009708.1.

3D structure databases

ProteinModelPortalA7FKF3.
SMRA7FKF3. Positions 30-522, 536-841.
ModBaseSearch...

Protein-protein interaction databases

STRING349747.YpsIP31758_2767.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS48911; ABS48911; YpsIP31758_2767.
GeneID5385153.
KEGGypi:YpsIP31758_2767.
PATRIC18634561. VBIYerPse15693_3214.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAIAQEDVV.
ProtClustDBPRK05560.

Family and domain databases

Gene3D1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA7FKF3_YERP3
AccessionPrimary (citable) accession number: A7FKF3
Entry history
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info