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A7FJU4

- PNCB_YERP3

UniProt

A7FJU4 - PNCB_YERP3

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciYPSE349747:GH71-2616-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:YpsIP31758_2557
    OrganismiYersinia pseudotuberculosis serotype O:1b (strain IP 31758)
    Taxonomic identifieri349747 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000002412: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 401401Nicotinate phosphoribosyltransferasePRO_1000061170Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349747.YpsIP31758_2557.

    Structurei

    3D structure databases

    ProteinModelPortaliA7FJU4.
    SMRiA7FJU4. Positions 5-377.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OMAiQAVFHRY.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7FJU4-1 [UniParc]FASTAAdd to Basket

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    MTQDASPILT SLLDTDAYKL HMQQAVFHHY RHITVAAEFR CRSDELLGVY    50
    ADEIRHQVTL MGQLALTSDE FIYLSSLPFF QDDYLHWLRD FRFKPEQVSV 100
    AVHDGKLDIR IAGLWCEVIM WEVPLLAVIS EIVHRRRSTQ VTTDQAVQQL 150
    RTKLEQFNAL SADIDITHFK LMDFGTRRRF SREIQHTVVS TLKDEFPYLV 200
    GTSNYDLART LALAPVGTQA HEWFQAHQQI SPTLANSQRV ALQVWLDEYP 250
    NQLGIALTDC ITMDAFLRDF DLAFANRYQG LRHDSGDPIE WGEKAIAHYE 300
    KLGIDPMKKV LVFSDNLDLE KALFLYRHFY QRIKLVFGIG TRLTCDIPDV 350
    KPLNIVIKLV ECNDKPVAKL SDSPGKTICQ DPAFVDQLRK AFALPLVKKA 400
    S 401
    Length:401
    Mass (Da):46,022
    Last modified:September 11, 2007 - v1
    Checksum:i88B37431DA649F2D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000720 Genomic DNA. Translation: ABS45898.1.
    RefSeqiYP_001401522.1. NC_009708.1.

    Genome annotation databases

    EnsemblBacteriaiABS45898; ABS45898; YpsIP31758_2557.
    GeneIDi5386510.
    KEGGiypi:YpsIP31758_2557.
    PATRICi18634111. VBIYerPse15693_2991.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000720 Genomic DNA. Translation: ABS45898.1 .
    RefSeqi YP_001401522.1. NC_009708.1.

    3D structure databases

    ProteinModelPortali A7FJU4.
    SMRi A7FJU4. Positions 5-377.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349747.YpsIP31758_2557.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS45898 ; ABS45898 ; YpsIP31758_2557 .
    GeneIDi 5386510.
    KEGGi ypi:YpsIP31758_2557.
    PATRICi 18634111. VBIYerPse15693_2991.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OMAi QAVFHRY.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci YPSE349747:GH71-2616-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever."
      Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G., Fayolle C., Lindler L.E., Carniel E., Ravel J.
      PLoS Genet. 3:1508-1523(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IP 31758.

    Entry informationi

    Entry nameiPNCB_YERP3
    AccessioniPrimary (citable) accession number: A7FJU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3