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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:YpsIP31758_2557
OrganismiYersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Taxonomic identifieri349747 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000002412 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000611701 – 401Nicotinate phosphoribosyltransferaseAdd BLAST401

Proteomic databases

PRIDEiA7FJU4

Structurei

3D structure databases

ProteinModelPortaliA7FJU4
SMRiA7FJU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000284928
KOiK00763
OMAiKLTMQCA

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

A7FJU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQDASPILT SLLDTDAYKL HMQQAVFHHY RHITVAAEFR CRSDELLGVY
60 70 80 90 100
ADEIRHQVTL MGQLALTSDE FIYLSSLPFF QDDYLHWLRD FRFKPEQVSV
110 120 130 140 150
AVHDGKLDIR IAGLWCEVIM WEVPLLAVIS EIVHRRRSTQ VTTDQAVQQL
160 170 180 190 200
RTKLEQFNAL SADIDITHFK LMDFGTRRRF SREIQHTVVS TLKDEFPYLV
210 220 230 240 250
GTSNYDLART LALAPVGTQA HEWFQAHQQI SPTLANSQRV ALQVWLDEYP
260 270 280 290 300
NQLGIALTDC ITMDAFLRDF DLAFANRYQG LRHDSGDPIE WGEKAIAHYE
310 320 330 340 350
KLGIDPMKKV LVFSDNLDLE KALFLYRHFY QRIKLVFGIG TRLTCDIPDV
360 370 380 390 400
KPLNIVIKLV ECNDKPVAKL SDSPGKTICQ DPAFVDQLRK AFALPLVKKA

S
Length:401
Mass (Da):46,022
Last modified:September 11, 2007 - v1
Checksum:i88B37431DA649F2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000720 Genomic DNA Translation: ABS45898.1
RefSeqiWP_002228013.1, NC_009708.1

Genome annotation databases

EnsemblBacteriaiABS45898; ABS45898; YpsIP31758_2557
KEGGiypi:YpsIP31758_2557

Similar proteinsi

Entry informationi

Entry nameiPNCB_YERP3
AccessioniPrimary (citable) accession number: A7FJU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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