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A7FJL1 (GCH1_YERP3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:YpsIP31758_2470
OrganismYersinia pseudotuberculosis serotype O:1b (strain IP 31758) [Complete proteome] [HAMAP]
Taxonomic identifier349747 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_1000058678

Sites

Metal binding1091Zinc By similarity
Metal binding1121Zinc By similarity
Metal binding1801Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
A7FJL1 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 5B497C8B4FA301F8

FASTA22024,714
        10         20         30         40         50         60 
MSSLSKEAEL VHQALLARGL ETPLRKPELD AETRKTRIQA HMTEVMHLLN LDLTDDSLAD 

        70         80         90        100        110        120 
TPRRIAKMYV DEIFSGLDYE NFPKITLIQN KMKVDEMVTV RDITLTSTCE HHFVTIDGKA 

       130        140        150        160        170        180 
TVAYIPKDSV IGLSKINRIV QFFAQRPQVQ ERLTQQILLA LQTLLGTNNV AVSIDAVHYC 

       190        200        210        220 
VKARGIRDAT SATTTTSLGG LFKSSQNTRQ EFLRAVRHHG 

« Hide

References

[1]"The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever."
Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G., Fayolle C., Lindler L.E., Carniel E., Ravel J.
PLoS Genet. 3:1508-1523(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IP 31758.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000720 Genomic DNA. Translation: ABS49180.1.
RefSeqYP_001401439.1. NC_009708.1.

3D structure databases

ProteinModelPortalA7FJL1.
SMRA7FJL1. Positions 3-219.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349747.YpsIP31758_2470.

Proteomic databases

PRIDEA7FJL1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS49180; ABS49180; YpsIP31758_2470.
GeneID5386406.
KEGGypi:YpsIP31758_2470.
PATRIC18633905. VBIYerPse15693_2889.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAVQFFSSR.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

BioCycYPSE349747:GH71-2527-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_YERP3
AccessionPrimary (citable) accession number: A7FJL1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways