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A7FHJ7

- MDTK_YERP3

UniProt

A7FHJ7 - MDTK_YERP3

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Protein

Multidrug resistance protein MdtK

Gene
mdtK, YpsIP31758_1750
Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Multidrug efflux pump that functions probably as a Na+/drug antiporter By similarity.UniRule annotation

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-HAMAP
  2. drug transmembrane transporter activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciYPSE349747:GH71-1794-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtK
Alternative name(s):
Multidrug-efflux transporter
Gene namesi
Name:mdtK
Ordered Locus Names:YpsIP31758_1750
OrganismiYersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Taxonomic identifieri349747 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000002412: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121Helical; Reviewed predictionAdd
BLAST
Transmembranei46 – 6621Helical; Reviewed predictionAdd
BLAST
Transmembranei93 – 11321Helical; Reviewed predictionAdd
BLAST
Transmembranei127 – 14721Helical; Reviewed predictionAdd
BLAST
Transmembranei160 – 18021Helical; Reviewed predictionAdd
BLAST
Transmembranei188 – 20821Helical; Reviewed predictionAdd
BLAST
Transmembranei243 – 26321Helical; Reviewed predictionAdd
BLAST
Transmembranei283 – 30119Helical; Reviewed predictionAdd
BLAST
Transmembranei316 – 33621Helical; Reviewed predictionAdd
BLAST
Transmembranei357 – 37721Helical; Reviewed predictionAdd
BLAST
Transmembranei387 – 40721Helical; Reviewed predictionAdd
BLAST
Transmembranei418 – 43821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Multidrug resistance protein MdtKUniRule annotationPRO_1000060798Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349747.YpsIP31758_1750.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000038538.
KOiK03327.
OMAiGGVGCGW.
OrthoDBiEOG6423C5.

Family and domain databases

HAMAPiMF_00400. MdtK.
InterProiIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A7FHJ7-1 [UniParc]FASTAAdd to Basket

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MQKYIVEARS LLALAIPVVI AQLSQTAMGV VDTIMAGSVS ATDMAAVAVG    50
TSIWLPAILF GHGLLLALTP TVAQLNGSGR RSQIAHQVRQ GFWLALCVSV 100
LIMLVLYNSD HVIKQMDNID PVLAQKAVGF LHAIMWGVPG YLFFQVLRNQ 150
CEGLSKTKPG MVIGFVGLLV NIPINYIFIY GKFGAPALGG VGCGVATASV 200
YWVMFLMMRW YVTRARSQQD IKLEKGFAAP DWQVMKRLSG LGLPVALALF 250
FEVTLFAVVA LLVSPLGIVA VAGHQIALNF SSLMFMLPMS LSVAATIRVG 300
FRLGQGSVEQ AQVAAYTSMA VGLLLASVTA VFTIVFREHI ALLYNKTPEV 350
VTMASHLMLL AALYQLSDAV QVIGSGVLRG YKDTRSIFFI TFTAYWLLGL 400
PSGYLLGLTD YILPAMGPAG FWIGFIIGLT AAAILMVLRI RWLQKQPTAF 450
ILQRAAH 457
Length:457
Mass (Da):49,417
Last modified:September 11, 2007 - v1
Checksum:i10C0928BD09546A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000720 Genomic DNA. Translation: ABS48394.1.
RefSeqiYP_001400725.1. NC_009708.1.

Genome annotation databases

EnsemblBacteriaiABS48394; ABS48394; YpsIP31758_1750.
GeneIDi5385365.
KEGGiypi:YpsIP31758_1750.
PATRICi18632338. VBIYerPse15693_2114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000720 Genomic DNA. Translation: ABS48394.1 .
RefSeqi YP_001400725.1. NC_009708.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349747.YpsIP31758_1750.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS48394 ; ABS48394 ; YpsIP31758_1750 .
GeneIDi 5385365.
KEGGi ypi:YpsIP31758_1750.
PATRICi 18632338. VBIYerPse15693_2114.

Phylogenomic databases

eggNOGi COG0534.
HOGENOMi HOG000038538.
KOi K03327.
OMAi GGVGCGW.
OrthoDBi EOG6423C5.

Enzyme and pathway databases

BioCyci YPSE349747:GH71-1794-MONOMER.

Family and domain databases

HAMAPi MF_00400. MdtK.
InterProi IPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view ]
Pfami PF01554. MatE. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00797. matE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever."
    Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G., Fayolle C., Lindler L.E., Carniel E., Ravel J.
    PLoS Genet. 3:1508-1523(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP 31758.

Entry informationi

Entry nameiMDTK_YERP3
AccessioniPrimary (citable) accession number: A7FHJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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