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A7FHA1

- A7FHA1_YERP3

UniProt

A7FHA1 - A7FHA1_YERP3

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Protein

Alanine racemase

Gene

alr1

Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei175 – 1751SubstrateUniRule annotation
Active sitei301 – 3011Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei349 – 3491Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciYPSE349747:GH71-1693-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr1Imported
Ordered Locus Names:YpsIP31758_1652Imported
OrganismiYersinia pseudotuberculosis serotype O:1b (strain IP 31758)Imported
Taxonomic identifieri349747 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000002412: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi349747.YpsIP31758_1652.

Structurei

3D structure databases

ProteinModelPortaliA7FHA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000279190.
KOiK01775.
OMAiQQIPCVA.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7FHA1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHVRFRHLFL LPLITLVACS QPVSKNHLSL TSLSANAQQP VVNNAWLEIS
60 70 80 90 100
QGALDFNTKK MLTLLDNKST LCAILKGDAY GHDLTLVTPV MLKNNVQCIG
110 120 130 140 150
VASNQELKTV RDLGFTGQLI RVRSATLKEM QQAMAYDVEE LIGDKTVAEQ
160 170 180 190 200
LNNIAKLNGK VLRIHLALNS AGMSRNGLEV SKARGLNDAK TIAGLKNLTI
210 220 230 240 250
VGIMSHYPVE DASEIKADLA RFQQQAKDVI AVTGLKREKI KLHVANTFAT
260 270 280 290 300
LAVPDSWLDM VRVGGVFYGD TIASTEYKRV MTFKSNIASL NNYPKGGTVG
310 320 330 340 350
YDRTYTLKRD SLLANIPVGY ADGYRRVFSN AGHVIIQGQR LPVLGKTSMN
360 370 380 390 400
TVIVDVTDLK KVSLGDEVVL FGKQGNAEIQ AEEIEDLSGA LFTEMSILWG

ATNKRILVD
Length:409
Mass (Da):44,770
Last modified:September 11, 2007 - v1
Checksum:iBBFCC8C5A2E4241C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000720 Genomic DNA. Translation: ABS49698.1.
RefSeqiYP_001400629.1. NC_009708.1.

Genome annotation databases

EnsemblBacteriaiABS49698; ABS49698; YpsIP31758_1652.
GeneIDi5388503.
KEGGiypi:YpsIP31758_1652.
PATRICi18632124. VBIYerPse15693_2010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000720 Genomic DNA. Translation: ABS49698.1 .
RefSeqi YP_001400629.1. NC_009708.1.

3D structure databases

ProteinModelPortali A7FHA1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349747.YpsIP31758_1652.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS49698 ; ABS49698 ; YpsIP31758_1652 .
GeneIDi 5388503.
KEGGi ypi:YpsIP31758_1652.
PATRICi 18632124. VBIYerPse15693_2010.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000279190.
KOi K01775.
OMAi QQIPCVA.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci YPSE349747:GH71-1693-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever."
    Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G., Fayolle C., Lindler L.E., Carniel E., Ravel J.
    PLoS Genet. 3:1508-1523(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP 31758Imported.

Entry informationi

Entry nameiA7FHA1_YERP3
AccessioniPrimary (citable) accession number: A7FHA1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 26, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3